Highly Enantioselective Kinetic Resolution of Michael Adducts through N-Heterocyclic Carbene Catalysis : An Efficient Asymmetric Route to Cyclohexenes
Chen, X.-Y., Li, S., Liu, Q., Kumar, M., Peuronen, A., Rissanen, K., & Enders, D. (2018). Highly Enantioselective Kinetic Resolution of Michael Adducts through N-Heterocyclic Carbene Catalysis : An Efficient Asymmetric Route to Cyclohexenes. Chemistry: A European Journal, 24(39), 9735-9738. https://doi.org/10.1002/chem.201802420
Published inChemistry: A European Journal
Li, Sun |
DisciplineEpäorgaaninen ja analyyttinen kemiaOrgaaninen kemiaNanoscience CenterInorganic and Analytical ChemistryOrganic ChemistryNanoscience Center
© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
Ahighly efficient strategy for the kinetic resolu-tion of Michael adductswas realized using achiral N-het-erocyclic carbene catalyst.The kinetic resolution providesanew convenientroute to single diastereomers of cyclo-hexenes and Michael adducts in good yields with highenantiomeric excesses (up to 99 % ee with aselectivityfactor of up to 458). This “two flies with one swat” con-cept allows the synthesis of these two synthetically valua-ble compound classes at the same time by asingle trans-formation.
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