Highly Enantioselective Kinetic Resolution of Michael Adducts through N-Heterocyclic Carbene Catalysis : An Efficient Asymmetric Route to Cyclohexenes
Abstract
Ahighly efficient strategy for the kinetic resolu-tion of Michael adductswas realized using achiral N-het-erocyclic carbene catalyst.The kinetic resolution providesanew convenientroute to single diastereomers of cyclo-hexenes and Michael adducts in good yields with highenantiomeric excesses (up to 99 % ee with aselectivityfactor of up to 458). This “two flies with one swat” con-cept allows the synthesis of these two synthetically valua-ble compound classes at the same time by asingle trans-formation.
Main Authors
Format
Articles
Research article
Published
2018
Series
Subjects
Publication in research information system
Publisher
Wiley
The permanent address of the publication
https://urn.fi/URN:NBN:fi:jyu-201807123535Käytä tätä linkitykseen.
Review status
Peer reviewed
ISSN
0947-6539
DOI
https://doi.org/10.1002/chem.201802420
Language
English
Published in
Chemistry: A European Journal
Citation
- Chen, X.-Y., Li, S., Liu, Q., Kumar, M., Peuronen, A., Rissanen, K., & Enders, D. (2018). Highly Enantioselective Kinetic Resolution of Michael Adducts through N-Heterocyclic Carbene Catalysis : An Efficient Asymmetric Route to Cyclohexenes. Chemistry: A European Journal, 24(39), 9735-9738. https://doi.org/10.1002/chem.201802420
License
Copyright© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim