Show simple item record

dc.contributor.authorMatomäki, Pekka
dc.contributor.authorKainulainen, Heikki
dc.contributor.authorKyröläinen, Heikki
dc.date.accessioned2018-06-28T09:06:45Z
dc.date.available2018-06-28T09:06:45Z
dc.date.issued2018
dc.identifier.citationMatomäki, P., Kainulainen, H., & Kyröläinen, H. (2018). Corrected whole blood biomarkers : the equation of Dill and Costill revisited. Physiological Reports, 6 (12), e13749. doi:10.14814/phy2.13749
dc.identifier.otherCONVID_28135725
dc.identifier.otherTUTKAID_78106
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/58765
dc.description.abstractAn exercise bout or a dehydration often causes a reduction in plasma volume, which should be acknowledged when considering the change in biomarkers before and after the plasma changing event. The classic equation from Dill and Costill (1974, J. Appl. Physiol., 37, 247–248) for plasma volume shift is usually utilized in such a case. Although this works well with plasma and serum biomarkers, we argue in this note that this traditional approach gives misleading results in the context of whole blood biomarkers, such as lactate, white cells, and thrombocytes. In this study, we demonstrate that to calculate the change in the total amount of circulating whole blood biomarker, one should utilize a formula BMpost BMpre Hbpre Hbpost 1: Here Hb and BM are, respectively, the concentrations for the hemoglobin and for the inspected whole blood biomarker before (pre) and after (post) the plasma changing incident.fi
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherWiley Periodicals; American Physiological Society; Physiological Society
dc.relation.ispartofseriesPhysiological Reports
dc.rightsCC BY 4.0
dc.subject.otherbiomarker
dc.subject.othercorrection formula
dc.subject.otherDill and Costill equation
dc.subject.otherplasma change
dc.titleCorrected whole blood biomarkers : the equation of Dill and Costill revisited
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201806273372
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineExercise Physiologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-06-27T12:15:05Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn2051-817X
dc.relation.numberinseries12
dc.relation.volume6
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 The Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysomarkkerit
dc.subject.ysoveri
dc.subject.ysoveriplasma
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p12288
jyx.subject.urihttp://www.yso.fi/onto/yso/p14506
jyx.subject.urihttp://www.yso.fi/onto/yso/p22516
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.14814/phy2.13749


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY 4.0
Except where otherwise noted, this item's license is described as CC BY 4.0