Time-Gated Raman Spectroscopy for Quantitative Determination of Solid-State Forms of Fluorescent Pharmaceuticals
Lipiäinen, T., Pessi, J., Movahedi, P., Koivistoinen, J., Kurki, L., Tenhunen, M., Yliruusi, J., Juppo, A. M., Heikkonen, J., Pahikkala, T., & Strachan, C. J. (2018). Time-Gated Raman Spectroscopy for Quantitative Determination of Solid-State Forms of Fluorescent Pharmaceuticals. Analytical Chemistry, 90(7), 4832-4839. https://doi.org/10.1021/acs.analchem.8b00298
Julkaistu sarjassa
Analytical ChemistryTekijät
Päivämäärä
2018Tekijänoikeudet
© 2018 American Chemical Society. This is a final draft version of an article whose final and definitive form has been published by American Chemical Society. Published in this repository with the kind permission of the publisher.
Raman spectroscopy is widely used for quantitative pharmaceutical analysis, but a common obstacle to its use is sample fluorescence masking the Raman signal. Time-gating provides an instrument-based method for rejecting fluorescence through temporal resolution of the spectral signal and allows Raman spectra of fluorescent materials to be obtained. An additional practical advantage is that analysis is possible in ambient lighting. This study assesses the efficacy of time-gated Raman spectroscopy for the quantitative measurement of fluorescent pharmaceuticals. Time-gated Raman spectroscopy with a 128 × (2) × 4 CMOS SPAD detector was applied for quantitative analysis of ternary mixtures of solid-state forms of the model drug, piroxicam (PRX). Partial least-squares (PLS) regression allowed quantification, with Raman-active time domain selection (based on visual inspection) improving performance. Model performance was further improved by using kernel-based regularized least-squares (RLS) regression with greedy feature selection in which the data use in both the Raman shift and time dimensions was statistically optimized. Overall, time-gated Raman spectroscopy, especially with optimized data analysis in both the spectral and time dimensions, shows potential for sensitive and relatively routine quantitative analysis of photoluminescent pharmaceuticals during drug development and manufacturing.
...
Julkaisija
American Chemical SocietyISSN Hae Julkaisufoorumista
0003-2700Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/27942545
Metadata
Näytä kaikki kuvailutiedotKokoelmat
Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
-
Fluorescent SMILES nanoparticles
Peuhu, Nelma (2024)Tämän opinnäytetyön kirjallisuuskatsaus käsittelee SMILES-materiaalien perusteoriaa sekä SMILES-nanopartikkeleiden valmistusta. Lisäksi tutkielmassa tarkastellaan analyyttisiä menetelmiä SMILES-nanopartikkeleiden optisten ... -
Real-time Fluorescence Measurement of Enterovirus Uncoating
Ruokolainen, Visa; Laajala, Mira; Marjomäki, Varpu (Bio-protocol, 2020)Viruses need to open, i.e., uncoat, in order to release their genomes for efficient replication and translation. Especially for non-enveloped viruses, such as enteroviruses, the cues leading to uncoating are less well ... -
Determination of the magnetic octupole moment of 173-Yb and a design towards laser-double resonance methods in an MR-ToF device
Kujanpää, Sonja (2020)Tämä pro gradu-tutkielma koostuu kahdesta osasta. Ensimmäisessä osassa stabiilin ytterbiumin magneettinen oktupolimomentti määritetään kollineaarista laserspektroskopiaa (CLS) ja nopeaa atomisuihkua käyttäen. Mittaus ... -
Quantitative Analysis of Dynamic Association in Live Biological Fluorescent Samples
Ruusuvuori, Pekka; Paavolainen, Lassi; Rutanen, Kalle; Mäki, Anita; Huttunen, Heikki; Marjomäki, Varpu (Public Library of Science, 2014)Determining vesicle localization and association in live microscopy may be challenging due to non-simultaneous imaging of rapidly moving objects with two excitation channels. Besides errors due to movement of objects, ... -
Identification of mixed bromidochloridotellurate anions in disordered crystal structures of (bdmim)2[TeX2Y4] (X, Y = Br, Cl; bdmim = 1-butyl-2,3-dimethylimidazolium) by combined application of Raman spectroscopy and solid-state DFT calculations
Närhi, Sari; Kutuniva, Johanna; Lajunen, Marja; Lahtinen, Manu; Tuononen, Heikki; Karttunen, Antti; Oilunkaniemi, Raija; Laitinen, Risto (Elsevier B.V., 2014)The discrete mixed [TeBrxCl6−x]2− anions in their disordered crystal structures have been identified by using the phases prepared by the reaction of 1-butyl-2,3-dimethylimidazolium halogenides (bdmim)X with tellurium ...
Ellei toisin mainittu, julkisesti saatavilla olevia JYX-metatietoja (poislukien tiivistelmät) saa vapaasti uudelleenkäyttää CC0-lisenssillä.