Modeling of intracellular transport in realistic cell geometries
The transport of molecules inside cells is a complex process, the
characterization of which is important to gain full understanding of cellular
processes. Understanding of intracellular transport is also important for
medical applications, for example when analyzing transport of medicine inside
cells. The intracellular environment is very complex, and at least the most
crucial parts of this complexity must be accounted for to solve transport
problems in cells. In this thesis the results of studies in modeling intracellular
transport are presented. The aim of the work was to model intracellular
transport of proteins and viral capsids in realistic cell environments. To this end,
microscopic methods were used to image cellular structures, which were then
digitally reconstructed and used as an environment for modeling particle
transport in numerical simulations.
Publisher
University of JyväskyläISBN
978-951-39-7385-8ISSN Search the Publication Forum
0075-465XKeywords
Metadata
Show full item recordCollections
- Väitöskirjat [3586]
License
Related items
Showing items with similar title or keywords.
-
Computational modeling of protein diffusion in the cell nucleus using the lattice-Boltzmann method
Filippovych, Kateryna (2012)The number of fluorescence applications and methods of analysis is growing in the biological and related sciences. The aim of this work was to accurately determine the diffusion coefficient in nucleus, diffusion in the ... -
Numerical methods for pricing options under jump-diffusion processes
Salmi, Santtu (University of Jyväskylä, 2013) -
Unbiased Inference for Discretely Observed Hidden Markov Model Diffusions
Chada, Neil K.; Franks, Jordan; Jasra, Ajay; Law, Kody J.; Vihola, Matti (Society for Industrial & Applied Mathematics (SIAM), 2021)We develop a Bayesian inference method for diffusions observed discretely and with noise, which is free of discretization bias. Unlike existing unbiased inference methods, our method does not rely on exact simulation ... -
High-Reynolds-number turbulent cavity flow using the lattice Boltzmann method
Hegele, L. A.; Scagliarini, A.; Sbragaglia, M.; Mattila, Keijo; Philippi, P. C.; Puleri, D. F.; Gounley, J.; Randles, A. (American Physical Society, 2018)We present a boundary condition scheme for the lattice Boltzmann method that has significantly improved stability for modeling turbulent flows while maintaining excellent parallel scalability. Simulations of a ... -
Localization and dimension estimation of attractors in the Glukhovsky-Dolzhansky system
Mokaev, Timur (University of Jyväskylä, 2016)