Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis
Deyou, T., Marco, M., Heydenreich, M., Pan, F., Gruhonjic, A., Fitzpatrick, P. A., Koch, A., Derese, S., Pelletier, J., Rissanen, K., Yenesew, A., & Erdélyi, M. (2017). Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis. Journal of Natural Products, 80(7), 2060-2066. https://doi.org/10.1021/acs.jnatprod.7b00255
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Journal of Natural ProductsAuthors
Date
2017Copyright
© 2017 American Chemical Society and American Society of Pharmacognosy. This is an open access article published under an ACS AuthorChoice License, which permits
copying and redistribution of the article or any adaptations for non-commercial purposes.
A new isoflavone, 8-prenylmilldrone (1), and four
new rotenoids, oblarotenoids A−D (2−5), along with nine known
compounds (6−14), were isolated from the CH2Cl2/CH3OH
(1:1) extract of the leaves of Millettia oblata ssp. teitensis by
chromatographic separation. The purified compounds were
identified by NMR spectroscopic and mass spectrometric analyses,
whereas the absolute configurations of the rotenoids were
established on the basis of chiroptical data and in some cases by
single-crystal X-ray crystallography. Maximaisoflavone J (11) and
oblarotenoid C (4) showed weak activity against the human breast
cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8
μM, respectively.
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American Chemical Society; American Society of PharmacognosyISSN Search the Publication Forum
0163-3864Keywords
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Except where otherwise noted, this item's license is described as © 2017 American Chemical Society and American Society of Pharmacognosy. This is an open access article published under an ACS AuthorChoice License, which permits
copying and redistribution of the article or any adaptations for non-commercial purposes.
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