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dc.contributor.authorWirta, Erkki-Ville
dc.contributor.authorSeppälä, Toni
dc.contributor.authorFriman, Marjukka
dc.contributor.authorVäyrynen, Juha
dc.contributor.authorAhtiainen, Maarit
dc.contributor.authorKautiainen, Hannu
dc.contributor.authorKuopio, Teijo
dc.contributor.authorKellokumpu, Ilmo
dc.contributor.authorMecklin, Jukka-Pekka
dc.contributor.authorBöhm, Jan
dc.date.accessioned2017-08-07T07:49:48Z
dc.date.available2017-08-07T07:49:48Z
dc.date.issued2017
dc.identifier.citationWirta, E.-V., Seppälä, T., Friman, M., Väyrynen, J., Ahtiainen, M., Kautiainen, H., Kuopio, T., Kellokumpu, I., Mecklin, J.-P., & Böhm, J. (2017). Immunoscore in Mismatch Repair-Proficient and -Deficient Colon Cancer. <i>Journal of Pathology</i>, <i>3</i>(3), 203-213. <a href="https://doi.org/10.1002/cjp2.71" target="_blank">https://doi.org/10.1002/cjp2.71</a>
dc.identifier.otherCONVID_26976625
dc.identifier.otherTUTKAID_73634
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/54997
dc.description.abstractThe aim of this study was to investigate immune response and its prognostic significance in colon carcinomas using the previously described Immunoscore (IS). A population-based series of 779 colorectal cancers, operated on between 2000 and 2010, were classified according to tumour, node, metastasis (TNM) status, mismatch repair (MMR), and BRAF mutation status. Rectal cancer cases (n 5 203) were excluded as a high proportion of these patients received preoperative neoadjuvant chemoradiotherapy. Tissue microarray (TMA) samples collected from the tumour centre and invasive front were immunostained for CD3 and CD8. Lymphocytes were then digitally calculated to categorize IS from grade 0 to 4. Samples adequate for IS were available from 510 tumours. IS was significantly associated with AJCC/UICC stage, T stage, lymph node and distant metastases, perineural and lymphovascular invasion, MMR status, and BRAF mutation status. For IS0, IS1, IS2, IS3 and IS4, respectively, the 5-year disease-free survival (DFS) rates were 59, 68, 78, 83 and 94% (p < 0.001); 5-year disease-specific survival (DSS) rates were 47, 55, 75, 80, and 89% (p < 0.001); and 5-year overall survival (OS) rates were 40, 44, 66, 61, and 76% (p < 0.001). IS was also prognostic for DFS, DSS, and OS within subsets of microsatellite-stable (MSS) and microsatellite-instable (MSI) disease. Multivariable analysis showed that IS, AJCC/UICC stage, lymphovascular invasion, and lymph node ratio in AJCC/UICC stage III disease were independent prognostic factors for DFS, DSS, and OS. Age was an independent prognostic factor for DSS and OS. Gender and BRAF mutation were independent prognostic factors for OS. In conclusion, IS differentiated patients with poor versus improved prognosis in MSS and MSI disease and across AJCC/ UICC stages. IS, AJCC/UICC stage, lymphovascular invasion, and lymph node ratio in AJCC/UICC stage III disease were independent prognostic factors for DFS, DSS, and OS.
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofseriesJournal of Pathology
dc.subject.otherpaksusuolisyötä
dc.subject.otherimmunoscore
dc.subject.othercolon cancer
dc.titleImmunoscore in Mismatch Repair-Proficient and -Deficient Colon Cancer
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201708043413
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineBiologiafi
dc.contributor.oppiaineBiologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-08-04T06:15:18Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange203-213
dc.relation.issn0022-3417
dc.relation.numberinseries3
dc.relation.volume3
dc.type.versionpublishedVersion
dc.rights.copyright© 2017 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.
dc.rights.accesslevelopenAccessfi
dc.subject.ysosyöpätaudit
dc.subject.ysoimmuunivaste
jyx.subject.urihttp://www.yso.fi/onto/yso/p678
jyx.subject.urihttp://www.yso.fi/onto/yso/p21599
dc.rights.urlhttps://creativecommons.org/licenses/by-nc/4.0/
dc.relation.doi10.1002/cjp2.71


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© 2017 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.
Except where otherwise noted, this item's license is described as © 2017 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.