Immunoscore in Mismatch Repair-Proficient and -Deficient Colon Cancer
Wirta, E.-V., Seppälä, T., Friman, M., Väyrynen, J., Ahtiainen, M., Kautiainen, H., Kuopio, T., Kellokumpu, I., Mecklin, J.-P., & Böhm, J. (2017). Immunoscore in Mismatch Repair-Proficient and -Deficient Colon Cancer. Journal of Pathology, 3(3), 203-213. https://doi.org/10.1002/cjp2.71
Julkaistu sarjassa
Journal of PathologyTekijät
Päivämäärä
2017Tekijänoikeudet
© 2017 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.
The aim of this study was to investigate immune response and its prognostic significance in colon carcinomas
using the previously described Immunoscore (IS). A population-based series of 779 colorectal cancers, operated
on between 2000 and 2010, were classified according to tumour, node, metastasis (TNM) status, mismatch
repair (MMR), and BRAF mutation status. Rectal cancer cases (n 5 203) were excluded as a high
proportion of these patients received preoperative neoadjuvant chemoradiotherapy. Tissue microarray (TMA)
samples collected from the tumour centre and invasive front were immunostained for CD3 and CD8. Lymphocytes
were then digitally calculated to categorize IS from grade 0 to 4. Samples adequate for IS were available
from 510 tumours. IS was significantly associated with AJCC/UICC stage, T stage, lymph node and distant
metastases, perineural and lymphovascular invasion, MMR status, and BRAF mutation status. For IS0, IS1, IS2,
IS3 and IS4, respectively, the 5-year disease-free survival (DFS) rates were 59, 68, 78, 83 and 94%
(p < 0.001); 5-year disease-specific survival (DSS) rates were 47, 55, 75, 80, and 89% (p < 0.001); and
5-year overall survival (OS) rates were 40, 44, 66, 61, and 76% (p < 0.001). IS was also prognostic for DFS,
DSS, and OS within subsets of microsatellite-stable (MSS) and microsatellite-instable (MSI) disease. Multivariable
analysis showed that IS, AJCC/UICC stage, lymphovascular invasion, and lymph node ratio in AJCC/UICC
stage III disease were independent prognostic factors for DFS, DSS, and OS. Age was an independent prognostic
factor for DSS and OS. Gender and BRAF mutation were independent prognostic factors for OS. In conclusion,
IS differentiated patients with poor versus improved prognosis in MSS and MSI disease and across AJCC/
UICC stages. IS, AJCC/UICC stage, lymphovascular invasion, and lymph node ratio in AJCC/UICC stage III disease
were independent prognostic factors for DFS, DSS, and OS.
...
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0022-3417Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/26976625
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Ellei muuten mainita, aineiston lisenssi on © 2017 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.
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Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment : a report from the prospective Lynch syndrome database
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