Efficacy of tailored exercise therapy on physical functioning in patients with knee osteoarthritis and comorbidity : A randomized controlled trial
Rooij, M. D., van der Leeden, M., Cheung, J., van der Esch, M., Häkkinen, A., Haverkamp, D., Roorda, L. D., Twisk, J., Vollebregt, J., Lems, W. F., & Dekker, J. (2017). Efficacy of tailored exercise therapy on physical functioning in patients with knee osteoarthritis and comorbidity : A randomized controlled trial. Arthritis Care and Research, 69(6), 807-816. https://doi.org/10.1002/acr.23013
Julkaistu sarjassa
Arthritis Care and ResearchTekijät
Päivämäärä
2017Tekijänoikeudet
© 2016, American College of Rheumatology. This is a final draft version of an article whose final and definitive form has been published by Wiley. Published in this repository with the kind permission of the publisher.
Objective
To evaluate the efficacy on physical functioning and safety of tailored exercise therapy in patients with knee osteoarthritis (OA) and comorbidities.
Methods
In a randomized controlled trial, 126 participants were included with a clinical diagnosis of knee OA and at least 1 of the following target comorbidities: coronary disease, heart failure, type 2 diabetes mellitus, chronic obstructive pulmonary disease, or obesity (body mass index ≥30 kg/m2), with severity score ≥2 on the Cumulative Illness Rating Scale. The intervention group received a 20-week, individualized, comorbidity-adapted exercise program consisting of aerobic and strength training and training of daily activities. The control group received their current medical care for knee OA and were placed on a waiting list for exercise therapy. Primary outcome measures were the Western Ontario and McMaster Universities Osteoarthritis Index, subscale physical functioning (WOMAC-pf), and the 6-minute walk test (6MWT). Measurements were performed at baseline, after 20 weeks (directly posttreatment), and at 3 months posttreatment.
Results
Statistically significant physical functioning differences over time were found between the intervention and control group (WOMAC: B = −7.43 [95% confidence interval (95% CI) −9.99, −4.87], P < 0.001; and 6MWT: B = 34.16 [95% CI 17.68, 50.64], P < 0.001) in favor of the intervention group. At 3 months followup, the mean improvements in the intervention group were 33% on the WOMAC scale and 15% on the 6MWT. These improvements are of clinical relevance. No serious adverse events occurred during the intervention.
Conclusion
This is the first study showing that tailored exercise therapy is efficacious in improving physical functioning and safe in patients with knee OA and severe comorbidities.
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Julkaisija
John Wiley & Sons, Inc.; American College of RheumatologyISSN Hae Julkaisufoorumista
2151-464XAsiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/26191661
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