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dc.contributor.authorFekete, Beáta
dc.contributor.authorPalkó, Márta
dc.contributor.authorHaukka, Matti
dc.contributor.authorFülöp, Ferenc
dc.date.accessioned2017-05-03T06:34:02Z
dc.date.available2017-05-03T06:34:02Z
dc.date.issued2017
dc.identifier.citationFekete, B., Palkó, M., Haukka, M., & Fülöp, F. (2017). Synthesis of Pyrrolo[1,2-a]pyrimidine Enantiomers via Domino Ring-Closure followed by Retro Diels-Alder Protocol. <em>Molecules</em>, 22 (4), 613. <a href="https://doi.org/10.3390/molecules22040613">doi:10.3390/molecules22040613</a>
dc.identifier.otherTUTKAID_73587
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/53750
dc.description.abstractFrom 2-aminonorbornene hydroxamic acids, a simple and efficient method for the preparation of pyrrolo[1,2-a]pyrimidine enantiomers is reported. The synthesis is based on domino ring-closure followed by microwave-induced retro Diels-Alder (RDA) protocols, where the chirality of the desired products is transferred from norbornene derivatives. The stereochemistry of the synthesized compounds was proven by X-ray crystallography. The absolute configuration of the product is determined by the configuration of the starting amino hydroxamic acid.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesMolecules
dc.subject.otherN-heterocycles
dc.subject.otherdomino reactions
dc.subject.otherhydroxamic acid
dc.subject.othermicrowave chemistry
dc.subject.otherretro Diels-Alder reaction
dc.titleSynthesis of Pyrrolo[1,2-a]pyrimidine Enantiomers via Domino Ring-Closure followed by Retro Diels-Alder Protocol
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201704242055
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineEpäorgaaninen ja analyyttinen kemia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-04-24T12:15:12Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn1420-3049
dc.relation.volume22
dc.type.versionpublishedVersion
dc.rights.copyright© the Authors, 2017. This is an open access article distributed under the Creative Commons Attribution License.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/molecules22040613


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© the Authors, 2017. This is an open access article distributed under the Creative Commons Attribution License.
Except where otherwise noted, this item's license is described as © the Authors, 2017. This is an open access article distributed under the Creative Commons Attribution License.