Palladium‐Catalyzed Domino Reaction for the Synthesis of 3‐Amino 1,2,4‐Benzothiadiazine 1,1‐Dioxides
Hommelsheim, R., van Nahl, R., Hanek, L. M., Ward, J. S., Rissanen, K., & Bolm, C. (2024). Palladium‐Catalyzed Domino Reaction for the Synthesis of 3‐Amino 1,2,4‐Benzothiadiazine 1,1‐Dioxides. Advanced Synthesis and Catalysis, 366(4), 717-724. https://doi.org/10.1002/adsc.202300875
Julkaistu sarjassa
Advanced Synthesis and CatalysisPäivämäärä
2024Tekijänoikeudet
© 2023 the Authors
A palladium‐catalyzed domino reaction of 2‐azidosulfonamides and isocyanides enables the synthesis of 3‐amino‐substituted 1,2,4‐benzothiadiazine 1,1‐dioxides at room temperature. By applying commercially available Pd(dba)2 in catalyst loadings as low as 1.0 mol%, a variety of 21 differently substituted 2H‐1,2,4‐benzothiadiazine 1,1‐dioxides can be prepared within 2 h. Moreover, the developed protocol gives access to the related 4H heterocycles.
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Wiley-VCH VerlagISSN Hae Julkaisufoorumista
1615-4150Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/194431999
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Fondsder Chemischen Industriee.V. (Kekulé scholarship) and Friedrich-Ebert-Stiftung (Promotionsförderung) are acknowledged for supporting the doctoral studies of RH. The authors thank Benjamin James Statham (RWTH Aachen University) for critical proof reading and fruitful discussion. We thank Mrs. Susanne Pohlman for her support with the synthesis of starting materials, Marcus Frings for the measu ...
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