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dc.contributor.authorLonn, Eija
dc.contributor.authorKoskela, Esa
dc.contributor.authorMappes, Tapio
dc.contributor.authorMökkönen, Mikael
dc.contributor.authorSims, Angela
dc.contributor.authorWatts, Phillip
dc.date.accessioned2017-04-11T05:31:19Z
dc.date.available2017-04-11T05:31:19Z
dc.date.issued2017
dc.identifier.citationLonn, E., Koskela, E., Mappes, T., Mökkönen, M., Sims, A., & Watts, P. (2017). Balancing selection maintains polymorphisms at neurogenetic loci in field experiments. <i>Proceedings of the National Academy of Sciences of the United States of America</i>, <i>114</i>(14), 3690-3695. <a href="https://doi.org/10.1073/pnas.1621228114" target="_blank">https://doi.org/10.1073/pnas.1621228114</a>
dc.identifier.otherCONVID_26927181
dc.identifier.otherTUTKAID_73372
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/53550
dc.description.abstractMost variation in behavior has a genetic basis, but the processes determining the level of diversity at behavioral loci are largely unknown for natural populations. Expression of arginine vasopressin receptor 1a (Avpr1a) and oxytocin receptor (Oxtr) in specific regions of the brain regulates diverse social and reproductive behaviors in mammals, including humans. That these genes have important fitness consequences and that natural populations contain extensive diversity at these loci implies the action of balancing selection. In Myodes glareolus, Avpr1a and Oxtr each contain a polymorphic microsatellite locus located in their 5′ regulatory region (the regulatory region-associated microsatellite, RRAM) that likely regulates gene expression. To test the hypothesis that balancing selection maintains diversity at behavioral loci, we released artificially bred females and males with different RRAM allele lengths into field enclosures that differed in population density. The length of Avpr1a and Oxtr RRAMs was associated with reproductive success, but population density and the sex interacted to determine the optimal genotype. In general, longer Avpr1a RRAMs were more beneficial for males, and shorter RRAMs were more beneficial for females; the opposite was true for Oxtr RRAMs. Moreover, Avpr1a RRAM allele length is correlated with the reproductive success of the sexes during different phases of reproduction; for males, RRAM length correlated with the numbers of newborn offspring, but for females selection was evident on the number of weaned offspring. This report of density-dependence and sexual antagonism acting on loci within the arginine vasopressin–oxytocin pathway explains how genetic diversity at Avpr1a and Oxtr could be maintained in natural populations.en
dc.language.isoeng
dc.publisherNational Academy of Sciences
dc.relation.ispartofseriesProceedings of the National Academy of Sciences of the United States of America
dc.subject.otherAvpr1a
dc.subject.otherMyodes glareolus
dc.subject.otherOxtr
dc.subject.otherdensity-dependent selection
dc.subject.othersexual conflict
dc.titleBalancing selection maintains polymorphisms at neurogenetic loci in field experiments
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201704071925
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.contributor.oppiaineEcology and Evolutionary Biologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-04-07T06:15:03Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange3690-3695
dc.relation.issn0027-8424
dc.relation.numberinseries14
dc.relation.volume114
dc.type.versionpublishedVersion
dc.rights.copyright© the Authors, 2017. Freely available online through the PNAS open access option.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber268670
dc.relation.doi10.1073/pnas.1621228114
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundinginformationWe thank the staff of the Experimental Animal Unit and Konnevesi Research Station, University of Jyväskylä, and S. Huttunen, S. Kyröläinen, P. Lehmann, M. Väätäinen, and T. Niittynen for logistical support; A. van t’Hof for cloning and sequencing; and E. Kallio, B. Crespi, the Crawford laboratory, three anonymous reviewers for insightful comments, and J. Valkonen for statistical advice. This work was supported by the Biological Interactions Doctoral Programme (E.L.); by Academy of Finland Grants 257340, 119200, 115961, and 140767 (to E.K.), 257729 (to M.M.), and 118603, 109165, 204284, and 268670 (to T.M.); and by the Center of Excellence in Evolutionary Research of the Academy of Finland.


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