Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy
Kangas, R., Törmäkangas, T., Fey, V., Pursiheimo, J., Miinalainen, I., Alen, M., Kaprio, J., Sipilä, S., Säämänen, A.-M., Kovanen, V., & Laakkonen, E. (2017). Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy. Scientific Reports, 7, Article 42702. https://doi.org/10.1038/srep42702
Published inScientific Reports
DisciplineGerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of Wellbeing
© 2017 the Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License.
Exosomes participate in intercellular messaging by transporting bioactive lipid-, protein- and RNA-molecules and -complexes. The contents of the exosomes reflect the physiological status of an individual making exosomes promising targets for biomarker analyses. In the present study we extracted exosome microRNAs (exomiRs) from serum samples of premenopausal women (n = 8) and monozygotic postmenopausal twins (n = 10 female pairs), discordant for the use of estrogenic hormone replacement therapy (HRT), in order to see whether the age or/and the use of HRT associates with exomiR content. A total of 241 exomiRs were detected by next generation sequencing, 10 showing age, 14 HRT and 10 age +HRT -related differences. When comparing the groups, differentially expressed miRs were predicted to affect cell proliferation processes showing inactivation with younger age and HRT usage. MiR-106-5p, -148a-3p, -27-3p, -126-5p, -28-3p and -30a-5p were significantly associated with serum 17β-estradiol. MiRs formed two hierarchical clusters being indicative of positive or negative health outcomes involving associations with body composition, serum 17β-estradiol, fat-, glucose- and inflammatory markers. Circulating exomiR clusters, obtained by NGS, could be used as indicators of metabolic and inflammatory status affected by hormonal changes at menopause. Furthermore, the individual effects of HRT-usage could be evaluated based on the serum exomiR signature. ...
PublisherNature Publishing Group
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Except where otherwise noted, this item's license is described as © 2017 the Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License.
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Ronkainen, Paula (University of Jyväskylä, 2010)
Circulating miR-21, miR-146a and Fas ligand respond to postmenopausal estrogen-based hormone replacement therapy : A study with monozygotic twin pairs Kangas, Reeta; Pöllänen, Eija; Rippo, Maria Rita; Lanzarini, Catia; Prattichizzo, Francesco; Niskala, Paula; Jylhävä, Juulia; Sipilä, Sarianna; Kaprio, Jaakko; Procopio, Antonio Domenico; Capri, Miriam; Franceschi, Claudio; Olivieri, Fabiola; Kovanen, Vuokko (Elsevier Ireland Ltd., 2014)Biological aging is associated with physiological deteriorations and its’ remodeling, which are partly due to changes in the hormonal profile. MicroRNAs are known to post-transcriptionally regulate various cellular processes ...
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