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dc.contributor.authorLönn, Eija
dc.date.accessioned2017-01-30T11:19:41Z
dc.date.available2017-01-30T11:19:41Z
dc.date.issued2017
dc.identifier.isbn978-951-39-6969-1
dc.identifier.otheroai:jykdok.linneanet.fi:1665684
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/52892
dc.description.abstractMost variation in behavior is regulated by genes; nevertheless the mechanisms behind maintenance of genetic diversity at behavioral loci have remained mainly elusive in natural populations. I studied in my thesis selection mechanisms of two genes associated with socio-sexual behavior, arginine vasopressin receptor 1a (Avpr1) and oxytocin receptor (Oxtr) in bank vole (Myodes glareolus). Expression of Avpr1a and Oxtr in specific regions of the brain regulates diverse social and reproductive behaviors such as parental care, aggression, sexual behavior, social recognition as well as pair and parent- offspring bonding in mammals. In addition, there is a link between the length of a regulatory region associated microsatellite (RRAM) of Avpr1 and receptor density in the brain in some species. Bank voles have highly polymorphic RRAM in Avpr1a and Oxtr. My first study revealed that different length variants of RRAM allele in Avpr1 and Oxtr genes are maintained by balancing selection; more precisely the selection is sex-specific and dependent on population density. Different allele lengths were favored in males compared to females indicating that Avpr1a and Oxtr are sexually antagonistic (SA) genes. My second study showed that intrasexual competition in both males and females drives selection of Avpr1a RRAM lengths. My third study evidenced that bank voles bias their offspring sex ratio to mitigate sexual conflict caused by the SA Oxtr gene. My fourth study showed that individuals with the extreme lengths of Avpr1 and Oxtr RRAMs experience constraints in breeding success indicating stabilizing selection. In conclusion, my thesis provides evidence for diverse mechanisms acting on genetic diversity of behavioral genes.
dc.format.extent1 verkkoaineisto (49 sivua) : kuvitettu
dc.language.isoeng
dc.publisherUniversity of Jyväskylä
dc.relation.ispartofseriesJyväskylä studies in biological and environmental science
dc.relation.isversionofYhteenveto-osa ja 4 eripainosta julkaistu myös painettuna.
dc.subject.otherselection
dc.subject.otherbehavioral genes
dc.subject.otherbank vole
dc.subject.otherOxtr
dc.subject.otherMyodes glareolus
dc.subject.otherAvpr1a
dc.titleSelection on two behavioral genes : fitness effects of receptor genes for arginine vasopressin 1a and oxytocin in the bank vole Myodes glareolus
dc.typeDiss.fi
dc.identifier.urnURN:ISBN:978-951-39-6969-1
dc.type.dcmitypeTexten
dc.type.ontasotVäitöskirjafi
dc.type.ontasotDoctoral dissertationen
dc.contributor.tiedekuntaMatemaattis-luonnontieteellinen tiedekuntafi
dc.contributor.tiedekuntaFaculty of Mathematics and Scienceen
dc.contributor.yliopistoUniversity of Jyväskyläen
dc.contributor.yliopistoJyväskylän yliopistofi
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.relation.issn1456-9701
dc.relation.numberinseries327
dc.rights.accesslevelopenAccessfi
dc.subject.ysoluonnonvalinta
dc.subject.ysokäyttäytyminen
dc.subject.ysolisääntymiskäyttäytyminen
dc.subject.ysogeenit
dc.subject.ysogeneettinen monimuotoisuus
dc.subject.ysokäyttäytymisgenetiikka
dc.subject.ysohormonit
dc.subject.ysoreseptorit
dc.subject.ysometsämyyrä


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