Systematic study of physicochemical properties of a homologous series of aminobisphosphonates
| dc.contributor.author | Alanne, Aino-Liisa | |
| dc.contributor.author | Hyvönen, Helena | |
| dc.contributor.author | Lahtinen, Manu | |
| dc.contributor.author | Ylisirniö, Markku | |
| dc.contributor.author | Turhanen, Petri | |
| dc.contributor.author | Kolehmainen, Erkki | |
| dc.contributor.author | Peräniemi, Sirpa | |
| dc.contributor.author | Vepsäläinen, Jouko | |
| dc.date.accessioned | 2016-12-19T07:43:23Z | |
| dc.date.available | 2016-12-19T07:43:23Z | |
| dc.date.issued | 2012 | |
| dc.identifier.citation | Alanne, A.-L., Hyvönen, H., Lahtinen, M., Ylisirniö, M., Turhanen, P., Kolehmainen, E., Peräniemi, S., & Vepsäläinen, J. (2012). Systematic study of physicochemical properties of a homologous series of aminobisphosphonates. <i>Molecules</i>, <i>17</i>(9), 10928-10945. <a href="https://doi.org/10.3390/molecules170910928" target="_blank">https://doi.org/10.3390/molecules170910928</a> | |
| dc.identifier.other | CONVID_21605873 | |
| dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/52415 | |
| dc.description.abstract | Aminobisphosphonates, e.g., alendronate and neridronate, are a well known class of molecules used as drugs for various bone diseases. Although these molecules have been available for decades, a detailed understanding of their most important physicochemical properties under comparable conditions is lacking. In this study, ten aminobisphosphonates, H2N(CH2)nC(OH)[P(O)(OH)2]2, in which n = 2–5, 7–11 and 15 have been synthesized. Their aqueous solubility as a function of temperature and pH, pKa-values, thermal stability, IR absorptions, and NMR spectral data for bothliquid (1H, 13C, 31P-NMR) and solid state (13C, 15N and 31P-CPMAS NMR) were determined. | |
| dc.language.iso | eng | |
| dc.publisher | MDPIAG | |
| dc.relation.ispartofseries | Molecules | |
| dc.subject.other | bisfosfonaatti | |
| dc.subject.other | vesiliuokoisuus | |
| dc.subject.other | happovakio | |
| dc.subject.other | fysikaaliskemialliset ominaisuudet | |
| dc.subject.other | aqueous solubility | |
| dc.subject.other | pKa | |
| dc.subject.other | physicochemical properties | |
| dc.title | Systematic study of physicochemical properties of a homologous series of aminobisphosphonates | |
| dc.type | research article | |
| dc.identifier.urn | URN:NBN:fi:jyu-201612165138 | |
| dc.contributor.laitos | Kemian laitos | fi |
| dc.contributor.laitos | Department of Chemistry | en |
| dc.contributor.oppiaine | Epäorgaaninen ja analyyttinen kemia | fi |
| dc.contributor.oppiaine | Inorganic and Analytical Chemistry | en |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
| dc.date.updated | 2016-12-16T13:15:08Z | |
| dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.description.reviewstatus | peerReviewed | |
| dc.format.pagerange | 10928-10945 | |
| dc.relation.issn | 1420-3049 | |
| dc.relation.numberinseries | 9 | |
| dc.relation.volume | 17 | |
| dc.type.version | publishedVersion | |
| dc.rights.copyright | © the Authors, 2012. This is an open access article distributed under the Creative Commons Attribution License. | |
| dc.rights.accesslevel | openAccess | fi |
| dc.type.publication | article | |
| dc.subject.yso | termoanalyysi | |
| dc.subject.yso | bisfosfonaatit | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p10178 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p23517 | |
| dc.rights.url | https://creativecommons.org/licenses/by-nc-sa/3.0/ | |
| dc.relation.doi | 10.3390/molecules170910928 | |
| dc.type.okm | A1 |
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