Systematic study of physicochemical properties of a homologous series of aminobisphosphonates
Alanne, A.-L., Hyvönen, H., Lahtinen, M., Ylisirniö, M., Turhanen, P., Kolehmainen, E., Peräniemi, S., & Vepsäläinen, J. (2012). Systematic study of physicochemical properties of a homologous series of aminobisphosphonates. Molecules, 17(9), 10928-10945. https://doi.org/10.3390/molecules170910928
Published in
MoleculesAuthors
Date
2012Copyright
© the Authors, 2012. This is an open access article distributed under the Creative Commons Attribution License.
Aminobisphosphonates, e.g., alendronate and neridronate, are a well known class of molecules used as drugs for various bone diseases. Although these molecules have been available for decades, a detailed understanding of their most important physicochemical properties under comparable conditions is lacking. In this study, ten aminobisphosphonates, H2N(CH2)nC(OH)[P(O)(OH)2]2, in which n = 2–5, 7–11 and 15 have been synthesized. Their aqueous solubility as a function of temperature and pH, pKa-values, thermal stability, IR absorptions, and NMR spectral data for bothliquid (1H, 13C, 31P-NMR) and solid state (13C, 15N and 31P-CPMAS NMR) were determined.
Publisher
MDPIAGISSN Search the Publication Forum
1420-3049Keywords
Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/21605873
Metadata
Show full item recordCollections
License
Except where otherwise noted, this item's license is described as © the Authors, 2012. This is an open access article distributed under the Creative Commons Attribution License.
Related items
Showing items with similar title or keywords.
-
Aqueous syntheses of anthracene-based mixed-ligand coordination polymers and their structural and optical properties
Marttinen, Antti; Lahtinen, Manu (Royal Society of Chemistry, 2024)Series of mixed-ligand coordination polymers (CP) and metal–organic frameworks (MOFs) based on bulky 9,10-di(1H-imidazol-1-yl)anthracene (dia) were synthesized from aqueous solutions even with very short (<10 min) reaction ... -
Single crystal investigations, Hirshfeld surface analysis, DFT studies, molecular docking, physicochemical characterization, antiferromagnetic behavior, and biological activity of Bis(Homopiperazinium)-Nickel Diaquatetrakis(Isothiocyanato)-Nickel
Makhlouf, Jawher; Louis, Hitler; Isang, Bartholomew B.; El Bakri, Youness; Okoro, Bernard; Valkonen, Arto; Abuelizz, Hatem A.; Al-Salahi, Rashad; Smirani Sta, Wajda (Elsevier, 2024)The purpose of the study is to synthesize and analyze the coordination compound [Ni(C5H12N2)2][Ni(NCS)4 2H2O]. The molecular structure of the Ni compound was established from single-crystal X-ray structure determination. ... -
Self-assembly, physico-chemical characterization, biological, virtual screening, and computational approach of novel 2-amino pyridine derivatives
Makhlouf, Jawher; El Bakri, Youness; Saravanan, Kandasamy; Valkonen, Arto; Smirani, Wajda (Elsevier BV, 2023)Two novel compounds, [Zn(SCN)4] (C5H7N2)2 (I) and (C5H7N2)NCS (II), were successfully synthesized and grown at room temperature by slow evaporation. The investigation of compound's properties was occurred using various ... -
Physico-Chemical Properties and Use of Waste Biomass-Derived Activated Carbons
Lahti, Riikka; Bergna, Davide; Romar, Henrik; Tuuttila, Tero; Hu, Tao; Lassi, Ulla (AIDIC, 2017)Activated carbons are widely used in different industrial processes for example as adsorbents or as support materials. Advantageously these carbons can be prepared from residual or waste biomass materials. Different raw ... -
Effects of biochar and hydrochar on soil physicochemical properties and greenhouse gas emissions from a legume grassland
Honkanen, Ella (2024)Biohiilen ja hydrohiilen käyttö maaperän lannoitteena on herättänyt viime vuosien aikana kiinnostusta niiden lukuisten hyötyjen vuoksi. Hiilen lisääminen maaperään parhaimmillaan edistää maaperän kykyä sitoa kasvihuoneka ...