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dc.contributor.authorKujala, Urho
dc.contributor.authorPeltonen, Markku
dc.contributor.authorLaine, Merja K.
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorHeinonen, Olli. J.
dc.contributor.authorSundvall, Jouko
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorJula, Antti
dc.contributor.authorSarna, Seppo
dc.contributor.authorKainulainen, Heikki
dc.date.accessioned2016-12-19T06:13:48Z
dc.date.available2016-12-19T06:13:48Z
dc.date.issued2016
dc.identifier.citationKujala, U., Peltonen, M., Laine, M. K., Kaprio, J., Heinonen, O. J., Sundvall, J., Eriksson, J. G., Jula, A., Sarna, S., & Kainulainen, H. (2016). Branched-Chain Amino Acid Levels Are Related with Surrogates of Disturbed Lipid Metabolism among Older Men. <i>Frontiers in Medicine</i>, <i>3</i>, 57. <a href="https://doi.org/10.3389/fmed.2016.00057" target="_blank">https://doi.org/10.3389/fmed.2016.00057</a>
dc.identifier.otherCONVID_26320430
dc.identifier.otherTUTKAID_71748
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/52410
dc.description.abstractAims/hypothesis: Existing studies suggest that decreased branched-chain amino acid (BCAA) catabolism and thus elevated levels in blood are associated with metabolic disturbances. Based on such information, we have developed a hypothesis how BCAA degradation mechanistically connects to tricarboxylic acid cycle, intramyocellular lipid storage, and oxidation, thus allowing more efficient mitochondrial energy production from lipids as well as providing better metabolic health. We analyzed whether data from aged Finnish men are in line with our mechanistic hypothesis linking BCAA catabolism and metabolic disturbances. Methods: Older Finnish men enriched with individuals having been athletes in young adulthood (n = 593; mean age 72.6 ± 5.9 years) responded to questionnaires, participated in a clinical examination including assessment of body composition with bioimpedance and gave fasting blood samples for various analytes as well as participated in a 2-h 75 g oral glucose tolerance test. Metabolomics measurements from serum included BCAAs (isoleucine, leucine, and valine). Results: Out of the 593 participants, 59 had previously known type 2 diabetes, further 67 had screen-detected type 2 diabetes, 127 impaired glucose tolerance, and 125 impaired fasting glucose, while 214 had normal glucose regulation and one had missing glucose tolerance information. There were group differences in all of the BCAA concentrations (p ≤ 0.005 for all BCAAs), such that those with normal glucose tolerance had the lowest and those with diabetes mellitus had the highest BCAA concentrations. All BCAA levels correlated positively with body fat percentage (r = 0.29–0.34, p < 0.0001 for all). Expected associations with high BCAA concentrations and unfavorable metabolic profile indicators from metabolomics analysis were found. Except for glucose concentrations, the associations were stronger with isoleucine and leucine than with valine. Conclusion/interpretation: The findings provided further support for our hypothesis by strengthening the idea that the efficiency of BCAA catabolism may be mechanistically involved in the regulation of fat oxidation, thus affecting the levels of metabolic disease risk factors.
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofseriesFrontiers in Medicine
dc.subject.otherbranched-chain amino acids
dc.subject.othermetabolic disease
dc.subject.othertricarboxylic acid cycle
dc.subject.otherlipid oxidation
dc.subject.otherenergy metabolism
dc.titleBranched-Chain Amino Acid Levels Are Related with Surrogates of Disturbed Lipid Metabolism among Older Men
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201611214690
dc.contributor.laitosLiikuntabiologian laitosfi
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Biology of Physical Activityen
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-11-21T10:15:04Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange57
dc.relation.issn2296-858X
dc.relation.numberinseries0
dc.relation.volume3
dc.type.versionpublishedVersion
dc.rights.copyright© 2016 Kujala, Peltonen, Laine, Kaprio, Heinonen, Sundvall, Eriksson, Jula, Sarna and Kainulainen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber298875
dc.subject.ysomitokondriot
jyx.subject.urihttp://www.yso.fi/onto/yso/p21158
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3389/fmed.2016.00057
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundinginformationThe study was funded by the Ministry of Education and Culture, the Juho Vainio Foundation, the Finnish Heart Research Foundation, Paavo Nurmi Foundation, the Finnish Cultural Foundation, the Academy of Finland (grants #265240 and 263278 to JK, and # 298875 to HK), and by a grant from Medical Society of Finland, Finska Läkaresällskapet.


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© 2016 Kujala, Peltonen, Laine, Kaprio, Heinonen, Sundvall, Eriksson, Jula, Sarna and Kainulainen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Except where otherwise noted, this item's license is described as © 2016 Kujala, Peltonen, Laine, Kaprio, Heinonen, Sundvall, Eriksson, Jula, Sarna and Kainulainen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).