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dc.contributor.authorVehniäinen, Eeva-Riikka
dc.contributor.authorBremer, Katharina
dc.contributor.authorScott, Jason A.
dc.contributor.authorJunttila, Sini
dc.contributor.authorLaiho, Asta
dc.contributor.authorGyenesei, Attila
dc.contributor.authorHodson, Peter V.
dc.contributor.authorOikari, Aimo
dc.date.accessioned2016-08-11T05:56:40Z
dc.date.available2016-08-11T05:56:40Z
dc.date.issued2016
dc.identifier.citationVehniäinen, E.-R., Bremer, K., Scott, J. A., Junttila, S., Laiho, A., Gyenesei, A., Hodson, P. V., & Oikari, A. (2016). Retene causes multifunctional transcriptomic changes in the heart of rainbow trout (Oncorhynchus mykiss) embryos. <i>Environmental Toxicology and Pharmacology</i>, <i>41</i>, 95-102. <a href="https://doi.org/10.1016/j.etap.2015.11.015" target="_blank">https://doi.org/10.1016/j.etap.2015.11.015</a>
dc.identifier.otherCONVID_25363661
dc.identifier.otherTUTKAID_68170
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/50928
dc.description.abstractFish are particularly sensitive to aryl hydrocarbon receptor (AhR)-mediated developmental toxicity. The molecular mechanisms behind these adverse effects have remained largely unresolved in salmonids, and for AhR-agonistic polycyclic aromatic hydrocarbons (PAHs). This study explored the cardiac transcriptome of rainbow trout (Oncorhynchus mykiss) eleuteroembryos exposed to retene, an AhR-agonistic PAH. The embryos were exposed to retene (nominal concentration 32 μg/L) and control, their hearts were collected before, at and after the onset of the visible signs of developmental toxicity, and transcriptomic changes were studied by microarray analysis. Retene up- or down-regulated 122 genes. The largest Gene Ontology groups were signal transduction, transcription, apoptosis, cell growth, cytoskeleton, cell adhesion/mobility, cardiovascular development, xenobiotic metabolism, protein metabolism, lipid metabolism and transport, and amino acid metabolism. Together these findings suggest that retene affects multiple signaling cascades in the heart of rainbow trout embryos, and potentially disturbs processes related to cardiovascular development and function.
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofseriesEnvironmental Toxicology and Pharmacology
dc.subject.otherdioxin-like toxicity
dc.subject.otherfish embryo
dc.subject.othertranscriptomics
dc.titleRetene causes multifunctional transcriptomic changes in the heart of rainbow trout (Oncorhynchus mykiss) embryos
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201608103761
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineYmpäristötiedefi
dc.contributor.oppiaineEnvironmental Scienceen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-08-10T15:15:09Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange95-102
dc.relation.issn1382-6689
dc.relation.numberinseries0
dc.relation.volume41
dc.type.versionacceptedVersion
dc.rights.copyright© Elsevier. This is a final draft version of an article whose final and definitive version has been published by Elsevier.
dc.rights.accesslevelopenAccessfi
dc.relation.doi10.1016/j.etap.2015.11.015


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