dc.contributor.author | Multanen, Juhani | |
dc.contributor.author | Heinonen, Ari | |
dc.contributor.author | Häkkinen, Arja | |
dc.contributor.author | Kautiainen, H. | |
dc.contributor.author | Kujala, Urho | |
dc.contributor.author | Lammentausta, E. | |
dc.contributor.author | Jämsä, T. | |
dc.contributor.author | Kiviranta, I. | |
dc.contributor.author | Nieminen, M.T. | |
dc.date.accessioned | 2016-07-07T10:20:54Z | |
dc.date.available | 2016-07-07T10:20:54Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Multanen, J., Heinonen, A., Häkkinen, A., Kautiainen, H., Kujala, U., Lammentausta, E., Jämsä, T., Kiviranta, I., & Nieminen, M.T. (2015). Bone and cartilage characteristics in postmenopausal women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis. <i>Journal of Musculoskeletal and Neuronal Interactions</i>, <i>15</i>(1), 69-77. <a href="http://www.ismni.org/jmni/pdf/59/08MULTANEN.pdf" target="_blank">http://www.ismni.org/jmni/pdf/59/08MULTANEN.pdf</a> | |
dc.identifier.other | CONVID_24674287 | |
dc.identifier.other | TUTKAID_65959 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/50755 | |
dc.description.abstract | Objectives: To evaluate the association between radiographically-assessed knee osteoarthritis and femoral neck bone characteristics
in women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis. Methods: Ninety postmenopausal
women (mean age [SD], 58 [4] years; height, 163 [6] cm; weight, 71 [11] kg) participated in this cross-sectional study. The severity
of radiographic knee osteoarthritis was defined using Kellgren-Lawrence grades 0=normal (n=12), 1=doubtful (n=25) or 2=minimal
(n=53). Femoral neck bone mineral content (BMC), section modulus (Z), and cross-sectional area (CSA) were measured with DXA.
The biochemical composition of ipsilateral knee cartilage was estimated using quantitative MRI measures, T2 mapping and dGEMRIC.
The associations between radiographic knee osteoarthritis grades and bone and cartilage characteristics were analyzed using generalized
linear models. Results: Age-, height-, and weight-adjusted femoral neck BMC (p for linearity=0.019), Z (p for linearity=0.033), and
CSA (p for linearity=0.019) increased significantly with higher knee osteoarthritis grades. There was no linear relationship between
osteoarthritis grades and knee cartilage indices. Conclusions: Increased DXAassessed hip bone strength isrelated to knee osteoarthritis
severity. These results are hypothesis driven that there is an inverse relationship between osteoarthritis and osteoporosis. However,
MRI assessed measures of cartilage do not discriminate mild radiographic osteoarthritis severity. | |
dc.language.iso | eng | |
dc.publisher | The International Society of Musculoskeletal and Neuronal Interactions | |
dc.relation.ispartofseries | Journal of Musculoskeletal and Neuronal Interactions | |
dc.relation.uri | http://www.ismni.org/jmni/pdf/59/08MULTANEN.pdf | |
dc.subject.other | Osteoarthritis | |
dc.subject.other | Bone Strength | |
dc.subject.other | Kellgren and Lawrence Grade | |
dc.subject.other | Quantitative MRI | |
dc.subject.other | Postmenopausal Women | |
dc.title | Bone and cartilage characteristics in postmenopausal women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201607063513 | |
dc.contributor.laitos | Terveystieteiden laitos | fi |
dc.contributor.laitos | Department of Health Sciences | en |
dc.contributor.oppiaine | Fysioterapia | fi |
dc.contributor.oppiaine | Liikuntalääketiede | fi |
dc.contributor.oppiaine | Physiotherapy | en |
dc.contributor.oppiaine | Sports and Exercise Medicine | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.date.updated | 2016-07-06T12:15:31Z | |
dc.type.coar | journal article | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 69-77 | |
dc.relation.issn | 1108-7161 | |
dc.relation.numberinseries | 1 | |
dc.relation.volume | 15 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © The authors, 2015. This is an open access article published by The International Society of Musculoskeletal and Neuronal Interactions. | |
dc.rights.accesslevel | openAccess | fi |