Bone and cartilage characteristics in postmenopausal women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis
Multanen, J., Heinonen, A., Häkkinen, A., Kautiainen, H., Kujala, U., Lammentausta, E., . . . Nieminen, M. T. (2015). Bone and cartilage characteristics in postmenopausal women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis. Journal of Musculoskeletal and Neuronal Interactions, 15 (1), 69-77. Retrieved from http://www.ismni.org/jmni/pdf/59/08MULTANEN.pdf
Published inJournal of Musculoskeletal and Neuronal Interactions
© The authors, 2015. This is an open access article published by The International Society of Musculoskeletal and Neuronal Interactions.
Objectives: To evaluate the association between radiographically-assessed knee osteoarthritis and femoral neck bone characteristics in women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis. Methods: Ninety postmenopausal women (mean age [SD], 58  years; height, 163  cm; weight, 71  kg) participated in this cross-sectional study. The severity of radiographic knee osteoarthritis was defined using Kellgren-Lawrence grades 0=normal (n=12), 1=doubtful (n=25) or 2=minimal (n=53). Femoral neck bone mineral content (BMC), section modulus (Z), and cross-sectional area (CSA) were measured with DXA. The biochemical composition of ipsilateral knee cartilage was estimated using quantitative MRI measures, T2 mapping and dGEMRIC. The associations between radiographic knee osteoarthritis grades and bone and cartilage characteristics were analyzed using generalized linear models. Results: Age-, height-, and weight-adjusted femoral neck BMC (p for linearity=0.019), Z (p for linearity=0.033), and CSA (p for linearity=0.019) increased significantly with higher knee osteoarthritis grades. There was no linear relationship between osteoarthritis grades and knee cartilage indices. Conclusions: Increased DXAassessed hip bone strength isrelated to knee osteoarthritis severity. These results are hypothesis driven that there is an inverse relationship between osteoarthritis and osteoporosis. However, MRI assessed measures of cartilage do not discriminate mild radiographic osteoarthritis severity. ...
PublisherThe International Society of Musculoskeletal and Neuronal Interactions
MetadataShow full item record
- Liikuntatieteiden tiedekunta