Bone and cartilage characteristics in postmenopausal women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis
Multanen, J., Heinonen, A., Häkkinen, A., Kautiainen, H., Kujala, U., Lammentausta, E., Jämsä, T., Kiviranta, I., & Nieminen, M. (2015). Bone and cartilage characteristics in postmenopausal women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis. Journal of Musculoskeletal and Neuronal Interactions, 15(1), 69-77. http://www.ismni.org/jmni/pdf/59/08MULTANEN.pdf
Published inJournal of Musculoskeletal and Neuronal Interactions
© The authors, 2015. This is an open access article published by The International Society of Musculoskeletal and Neuronal Interactions.
Objectives: To evaluate the association between radiographically-assessed knee osteoarthritis and femoral neck bone characteristics in women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis. Methods: Ninety postmenopausal women (mean age [SD], 58  years; height, 163  cm; weight, 71  kg) participated in this cross-sectional study. The severity of radiographic knee osteoarthritis was defined using Kellgren-Lawrence grades 0=normal (n=12), 1=doubtful (n=25) or 2=minimal (n=53). Femoral neck bone mineral content (BMC), section modulus (Z), and cross-sectional area (CSA) were measured with DXA. The biochemical composition of ipsilateral knee cartilage was estimated using quantitative MRI measures, T2 mapping and dGEMRIC. The associations between radiographic knee osteoarthritis grades and bone and cartilage characteristics were analyzed using generalized linear models. Results: Age-, height-, and weight-adjusted femoral neck BMC (p for linearity=0.019), Z (p for linearity=0.033), and CSA (p for linearity=0.019) increased significantly with higher knee osteoarthritis grades. There was no linear relationship between osteoarthritis grades and knee cartilage indices. Conclusions: Increased DXAassessed hip bone strength isrelated to knee osteoarthritis severity. These results are hypothesis driven that there is an inverse relationship between osteoarthritis and osteoporosis. However, MRI assessed measures of cartilage do not discriminate mild radiographic osteoarthritis severity. ...
PublisherThe International Society of Musculoskeletal and Neuronal Interactions
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Showing items with similar title or keywords.
Association between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis Hirvasniemi, Jukka; Thevenot, Jérôme; Multanen, Juhani; Haapea, Marianne; Heinonen, Ari; Nieminen, Miika T.; Saarakkala, Simo (Elsevier Ltd; OsteoArthritis Research Society International, 2017)Objective: Our aim was to investigate the relation between radiograph-based subchondral bone structure and cartilage composition assessed with delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) ...
Multanen, Juhani (University of Jyväskylä, 2016)The purpose of this study was to investigate the effects of high-impact exercise on bone mineral mass and strength, and on knee cartilage composition in postmenopausal women with mild knee osteoarthritis (OA). In ...
Efficacy of Progressive Aquatic Resistance Training for Tibiofemoral Cartilage in Postmenopausal Women with Mild Knee Osteoarthritis : A Randomised Controlled Trial Munukka, Matti; Waller, Benjamin; Rantalainen, Timo; Häkkinen, Arja; Nieminen, Miika T.; Lammentausta, Eveliina; Kujala, Urho; Paloneva, Juha; Sipilä, Sarianna; Peura, Arttu; Kautiainen, Hannu; Selänne, Harri; Kiviranta, Ilkka; Heinonen, Ari (Elsevier Ltd, 2016)Objective To study the efficacy of aquatic resistance training on biochemical composition of tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis (OA). Design Eighty seven volunteer ...
Relationship between lower limb neuromuscular performance and bone strength in postmenopausal women with mild knee osteoarthritis Munukka, Matti; Waller, Benjamin; Multanen, Juhani; Rantalainen, T.; Häkkinen, Arja; Nieminen, M.T.; Lammentausta, E.; Kujala, Urho; Paloneva, J.; Kautiainen, H.; Kiviranta, I.; Heinonen, Ari (The International Society of Musculoskeletal and Neuronal Interactions, 2014)Objectives: To investigate whether neuromuscular performance predicts lower limb bone strength in different lower limb sites in postmenopausal women with mild knee osteoarthritis (OA). Methods: Neuromuscular performance ...
Munukka, Matti (Jyväskylän yliopisto, 2018)Knee osteoarthritis (OA) is a leading cause of musculoskeletal pain and disability and has significant socio-economical costs globally. There is no known cure for OA. Therapeutic exercise has been shown to evoke acute ...