N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis
Nyandoro, S. S., Ndanu, J., Munissi, J. J. E., Gruhonjic, A., Fitzpatrick, P. A., Landberg, G., Lu, Y., Wang, B., Pan, F., Rissanen, K., & Erdélyi, M. (2015). N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis. Journal of Natural Products, 78(8), 2045-2050. https://doi.org/10.1021/acs.jnatprod.5b00356
Published inJournal of Natural Products
Lu, Yu |
© the Authors, 2015. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Seven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cell line.
PublisherAmerican Society of Pharmacognosy
ISSN Search the Publication Forum0163-3864
Publication in research information system
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Except where otherwise noted, this item's license is described as © the Authors, 2015. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
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