N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis
Abstract
Seven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine
E (2), toussaintine F (6), and toussaintine G (7), were isolated from
the methanol extract of the leaves of Toussaintia orientalis using column
chromatography and HPLC. The configurations of E-toussaintine E (1) and
toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction
data from racemic crystals. Both the crude methanol extract and the isolated
constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the
H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic
(ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast
cancer cell line.
Main Authors
Format
Articles
Research article
Published
2015
Series
Subjects
Publication in research information system
Publisher
American Society of Pharmacognosy
The permanent address of the publication
https://urn.fi/URN:NBN:fi:jyu-201606303417Use this for linking
Review status
Peer reviewed
ISSN
0163-3864
DOI
https://doi.org/10.1021/acs.jnatprod.5b00356
Language
English
Published in
Journal of Natural Products
Citation
- Nyandoro, S. S., Ndanu, J., Munissi, J. J. E., Gruhonjic, A., Fitzpatrick, P. A., Landberg, G., Lu, Y., Wang, B., Pan, F., Rissanen, K., & Erdélyi, M. (2015). N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis. Journal of Natural Products, 78(8), 2045-2050. https://doi.org/10.1021/acs.jnatprod.5b00356
License
Copyright© the Authors, 2015. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.