N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis
Nyandoro, S. S., Ndanu, J., Munissi, J. J. E., Gruhonjic, A., Fitzpatrick, P. A., Landberg, G., Lu, Y., Wang, B., Pan, F., Rissanen, K., & Erdélyi, M. (2015). N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis. Journal of Natural Products, 78(8), 2045-2050. https://doi.org/10.1021/acs.jnatprod.5b00356
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Journal of Natural ProductsAuthors
Lu, Yu |
Date
2015Copyright
© the Authors, 2015. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Seven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine
E (2), toussaintine F (6), and toussaintine G (7), were isolated from
the methanol extract of the leaves of Toussaintia orientalis using column
chromatography and HPLC. The configurations of E-toussaintine E (1) and
toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction
data from racemic crystals. Both the crude methanol extract and the isolated
constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the
H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic
(ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast
cancer cell line.
Publisher
American Society of PharmacognosyISSN Search the Publication Forum
0163-3864Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/24860585
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Except where otherwise noted, this item's license is described as © the Authors, 2015. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.