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dc.contributor.authorCREAM consortium
dc.date.accessioned2016-06-03T09:46:02Z
dc.date.available2016-06-03T09:46:02Z
dc.date.issued2016
dc.identifier.citationCREAM consortium. (2016). Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium. <i>Scientific Reports</i>, <i>6</i>, Article 25853. <a href="https://doi.org/10.1038/srep25853" target="_blank">https://doi.org/10.1038/srep25853</a>
dc.identifier.otherCONVID_26037756
dc.identifier.otherTUTKAID_70216
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/50070
dc.description.abstractMyopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset of association between genetic variants at these 39 loci and refractive error was investigated in 5200 children assessed longitudinally across ages 7–15 years, along with gene-environment interactions involving the major environmental risk-factors, nearwork and time outdoors. Specific variants could be categorized as showing evidence of: (a) early-onset effects remaining stable through childhood, (b) early-onset effects that progressed further with increasing age, or (c) onset later in childhood (N=10, 5 and 11 variants, respectively). A genetic risk score (GRS) for all 39 variants explained 0.6% (P=6.6E–08) and 2.3% (P=6.9E–21) of the variance in refractive error at ages 7 and 15, respectively, supporting increased effects from these genetic variants at older ages. Replication in multi-ancestry samples (combined N=5599) yielded evidence of childhood onset for 6 of 12 variants present in both Asians and Europeans. There was no indication that variant or GRS effects altered depending on time outdoors, however 5 variants showed nominal evidence of interactions with nearwork (top variant, rs7829127 in ZMAT4; P=6.3E–04).
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.subject.otherrefractive error
dc.subject.othergene-environment interaction
dc.subject.otherage-of-onset
dc.subject.othergenetic variants
dc.titleChildhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201606022826
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-06-02T12:15:03Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.numberinseries0
dc.relation.volume6
dc.type.versionpublishedVersion
dc.rights.copyright© the Authors, 2016. This is an open access article published by Nature Publishing Group and distributed under a Creative Commons Attribution 4.0 International License.
dc.rights.accesslevelopenAccessfi
dc.subject.ysolikinäköisyys
jyx.subject.urihttp://www.yso.fi/onto/yso/p5995
dc.rights.urlhttp://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/srep25853


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© the Authors, 2016. This is an open access article published by Nature Publishing Group and distributed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as © the Authors, 2016. This is an open access article published by Nature Publishing Group and distributed under a Creative Commons Attribution 4.0 International License.