Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
| dc.contributor.author | CREAM consortium | |
| dc.date.accessioned | 2016-04-29T05:39:31Z | |
| dc.date.available | 2016-04-29T05:39:31Z | |
| dc.date.issued | 2016 | |
| dc.identifier.citation | CREAM consortium. (2016). Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error. <i>Nature Communications</i>, <i>7</i>, Article 11008. <a href="https://doi.org/10.1038/ncomms11008" target="_blank">https://doi.org/10.1038/ncomms11008</a> | |
| dc.identifier.other | CONVID_25674324 | |
| dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/49594 | |
| dc.description.abstract | Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test singlenucleotide polymorphism (SNP) main effects and SNP education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (Po8.5 10 5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia. | |
| dc.language.iso | eng | |
| dc.publisher | Nature Publishing Group | |
| dc.relation.ispartofseries | Nature Communications | |
| dc.subject.other | single-nucleotide polymorphism | |
| dc.subject.other | loci | |
| dc.subject.other | education | |
| dc.title | Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error | |
| dc.type | research article | |
| dc.identifier.urn | URN:NBN:fi:jyu-201604282358 | |
| dc.contributor.laitos | Terveystieteiden laitos | fi |
| dc.contributor.laitos | Department of Health Sciences | en |
| dc.contributor.oppiaine | Gerontologia ja kansanterveys | fi |
| dc.contributor.oppiaine | Gerontologian tutkimuskeskus | fi |
| dc.contributor.oppiaine | Hyvinvoinnin tutkimuksen yhteisö | fi |
| dc.contributor.oppiaine | Gerontology and Public Health | en |
| dc.contributor.oppiaine | Gerontology Research Center | en |
| dc.contributor.oppiaine | School of Wellbeing | en |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
| dc.date.updated | 2016-04-28T15:15:03Z | |
| dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.description.reviewstatus | peerReviewed | |
| dc.relation.issn | 2041-1723 | |
| dc.relation.numberinseries | 0 | |
| dc.relation.volume | 7 | |
| dc.type.version | publishedVersion | |
| dc.rights.copyright | © the Authors 2016. This is an open access article published by Nature and licensed under a Creative Commons Attribution 4.0 International License. | |
| dc.rights.accesslevel | openAccess | fi |
| dc.type.publication | article | |
| dc.subject.yso | likinäköisyys | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p5995 | |
| dc.rights.url | http://creativecommons.org/licenses/by/4.0/ | |
| dc.relation.doi | 10.1038/ncomms11008 | |
| dc.type.okm | A1 |
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Ellei muuten mainita, aineiston lisenssi on © the Authors 2016. This is an open access article published by Nature and licensed under a Creative Commons Attribution 4.0 International License.