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dc.contributor.authorNokia, Miriam
dc.contributor.authorLensu, Sanna
dc.contributor.authorAhtiainen, Juha
dc.contributor.authorJohansson, Petra P.
dc.contributor.authorKoch, Lauren G.
dc.contributor.authorBritton, Steven L.
dc.contributor.authorKainulainen, Heikki
dc.date.accessioned2016-04-08T11:05:00Z
dc.date.available2017-02-24T22:45:06Z
dc.date.issued2016
dc.identifier.citationNokia, M., Lensu, S., Ahtiainen, J., Johansson, P. P., Koch, L. G., Britton, S. L., & Kainulainen, H. (2016). Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained. <em>Journal of Physiology</em>, 594 (7), 1855-1873. <a href="http://dx.doi.org/10.1113/JP271552">doi:10.1113/JP271552</a>
dc.identifier.otherTUTKAID_69243
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/49287
dc.description.abstractAerobic exercise, such as running, has positive effects on brain structure and function, such as adult hippocampal neurogenesis (AHN) and learning. Whether high-intensity interval training (HIT), referring to alternating short bouts of very intense anaerobic exercise with recovery periods, or anaerobic resistance training (RT) has similar effects on AHN is unclear. In addition, individual genetic variation in the overall response to physical exercise is likely to play a part in the effects of exercise on AHN but is less well studied. Recently, we developed polygenic rat models that gain differentially for running capacity in response to aerobic treadmill training. Here, we subjected these low-response trainer (LRT) and high-response trainer (HRT) adult male rats to various forms of physical exercise for 6–8 weeks and examined the effects on AHN. Compared with sedentary animals, the highest number of doublecortin-positive hippocampal cells was observed in HRT rats that ran voluntarily on a running wheel, whereas HIT on the treadmill had a smaller, statistically non-significant effect on AHN. Adult hippocampal neurogenesis was elevated in both LRT and HRT rats that underwent endurance training on a treadmill compared with those that performed RT by climbing a vertical ladder with weights, despite their significant gain in strength. Furthermore, RT had no effect on proliferation (Ki67), maturation (doublecortin) or survival (bromodeoxyuridine) of new adult-born hippocampal neurons in adult male Sprague–Dawley rats. Our results suggest that physical exercise promotes AHN most effectively if the exercise is aerobic and sustained, especially when accompanied by a heightened genetic predisposition for response to physical exercise.
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing Ltd.; Physiological Society, London
dc.relation.ispartofseriesJournal of Physiology
dc.subject.otherphysical exercise
dc.subject.otherhippocampal neurogenesis
dc.subject.otherhigh-intensity interval training
dc.subject.otherHIT
dc.subject.otheranaerobic resistance training
dc.subject.otherAHN
dc.subject.otherrats
dc.titlePhysical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201604072023
dc.contributor.laitosLiikuntabiologian laitosfi
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Biology of Physical Activityen
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiaineLiikuntafysiologia
dc.contributor.oppiaineValmennus- ja testausoppi
dc.contributor.oppiainePsykologia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-04-07T09:15:04Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1855-1873
dc.relation.issn0022-3751
dc.relation.volume594
dc.type.versionacceptedVersion
dc.rights.copyright© 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society. This is a final draft version of an article whose final and definitive form has been published by Wiley. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.relation.doi10.1113/JP271552


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