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Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained

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Nokia, M., Lensu, S., Ahtiainen, J., Johansson, P. P., Koch, L. G., Britton, S. L., & Kainulainen, H. (2016). Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained. Journal of Physiology, 594(7), 1855-1873. https://doi.org/10.1113/JP271552
Published in
Journal of Physiology
Authors
Nokia, Miriam |
Lensu, Sanna |
Ahtiainen, Juha |
Johansson, Petra P. |
Koch, Lauren G. |
Britton, Steven L. |
Kainulainen, Heikki
Date
2016
Discipline
PsykologiaLiikuntafysiologiaValmennus- ja testausoppiPsychologyExercise PhysiologyScience of Sport Coaching and Fitness Testing
Copyright
© 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society. This is a final draft version of an article whose final and definitive form has been published by Wiley. Published in this repository with the kind permission of the publisher.

 
Aerobic exercise, such as running, has positive effects on brain structure and function, such as adult hippocampal neurogenesis (AHN) and learning. Whether high-intensity interval training (HIT), referring to alternating short bouts of very intense anaerobic exercise with recovery periods, or anaerobic resistance training (RT) has similar effects on AHN is unclear. In addition, individual genetic variation in the overall response to physical exercise is likely to play a part in the effects of exercise on AHN but is less well studied. Recently, we developed polygenic rat models that gain differentially for running capacity in response to aerobic treadmill training. Here, we subjected these low-response trainer (LRT) and high-response trainer (HRT) adult male rats to various forms of physical exercise for 6–8 weeks and examined the effects on AHN. Compared with sedentary animals, the highest number of doublecortin-positive hippocampal cells was observed in HRT rats that ran voluntarily on a running wheel, whereas HIT on the treadmill had a smaller, statistically non-significant effect on AHN. Adult hippocampal neurogenesis was elevated in both LRT and HRT rats that underwent endurance training on a treadmill compared with those that performed RT by climbing a vertical ladder with weights, despite their significant gain in strength. Furthermore, RT had no effect on proliferation (Ki67), maturation (doublecortin) or survival (bromodeoxyuridine) of new adult-born hippocampal neurons in adult male Sprague–Dawley rats. Our results suggest that physical exercise promotes AHN most effectively if the exercise is aerobic and sustained, especially when accompanied by a heightened genetic predisposition for response to physical exercise. ...
Publisher
Wiley-Blackwell Publishing Ltd.; Physiological Society, London
ISSN Search the Publication Forum
0022-3751
Keywords
physical exercise hippocampal neurogenesis high-intensity interval training HIT anaerobic resistance training AHN rats
DOI
https://doi.org/10.1113/JP271552
URI

http://urn.fi/URN:NBN:fi:jyu-201604072023

Publication in research information system

https://converis.jyu.fi/converis/portal/detail/Publication/25559246

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  • Liikuntatieteiden tiedekunta [2403]
  • Yhteiskuntatieteellinen tiedekunta 31.12.2016 saakka [495]
Related funder(s)
Academy of Finland
Funding program(s)
Academy Programme, AoF; Academy Research Fellow, AoF
Additional information about funding
This work was supported by the Academy of Finland (grant no. 274098 to H.K., and grant nos 137783 and 275954 to M.S.N.), the Finnish Cultural Foundation (H.K.), METAPREDICT within the European Union Seventh Framework Program (HEALTH‐F2‐2012‐277936 to H.K.) and the National Institutes of Health (R24OD010950 to L.G.K. and S.L.B., and 3P60DK020572‐32S2 and 5P60 DK20572‐P/FS to L.G.K.).

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