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dc.contributor.authorDehghan, Abbas
dc.contributor.authorBis, Joshua C.
dc.contributor.authorWhite, Charles C.
dc.contributor.authorSmith, Albert Vernon
dc.contributor.authorMorrison, Alanna C.
dc.contributor.authorCupples, L. Adrienne
dc.contributor.authorTrompet, Stella
dc.contributor.authorChasman, Daniel I.
dc.contributor.authorLumley, Thomas
dc.contributor.authorVölker, Uwe
dc.contributor.authorBuckley, Brendan M.
dc.contributor.authorDing, Jingzhong
dc.contributor.authorJensen, Majken K.
dc.contributor.authorFolsom, Aaron R.
dc.contributor.authorKritchevsky, Stephen B.
dc.contributor.authorGirman, Cynthia J.
dc.contributor.authorFord, Ian
dc.contributor.authorDörr, Marcus
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorUitterlinden, André G.
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorVasan, Ramachandran S.
dc.contributor.authorFranceschini, Nora
dc.contributor.authorCarty, Cara L.
dc.contributor.authorVirtamo, Jarmo
dc.contributor.authorDemissie, Serkalem
dc.contributor.authorAmouyel, Philippe
dc.contributor.authorArveiler, Dominique
dc.contributor.authorHeckbert, Susan R.
dc.contributor.authorFerrières, Jean
dc.contributor.authorDucimetière, Pierre
dc.contributor.authorSmith, Nicholas L.
dc.contributor.authorWang, Ying A.
dc.contributor.authorSiscovick, David S.
dc.contributor.authorRice, Kenneth M.
dc.contributor.authorWiklund, Per-Gunnar
dc.contributor.authorTaylor, Kent D.
dc.contributor.authorEvans, Alun
dc.contributor.authorKee, Frank
dc.contributor.authorRotter, Jerome I.
dc.contributor.authorKarvanen, Juha
dc.contributor.authorKuulasmaa, Kari
dc.contributor.authorHeiss, Gerardo
dc.contributor.authorKraft, Peter
dc.contributor.authorLauner, Lenore J.
dc.contributor.authorHofman, Albert
dc.contributor.authorMarkus, Marcello R. P.
dc.contributor.authorRose, Lynda M.
dc.contributor.authorSilander, Kaisa
dc.contributor.authorWagner, Peter
dc.contributor.authorBenjamin, Emelia J.
dc.contributor.authorLohman, Kurt
dc.contributor.authorStott, David J.
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorLevy, Daniel
dc.contributor.authorLiu, Yongmei
dc.contributor.authorRimm, Eric B.
dc.contributor.authorJukema, J. Wouter
dc.contributor.authorVölzke, Henry
dc.contributor.authorRidker, Paul M.
dc.contributor.authorBlankenberg, Stefan
dc.contributor.authorFranco, Oscar H.
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorO'Donnell, Christopher J.
dc.date.accessioned2016-03-16T09:56:06Z
dc.date.available2016-03-16T09:56:06Z
dc.date.issued2016
dc.identifier.citationDehghan, A., Bis, J. C., White, C. C., Smith, A. V., Morrison, A. C., Cupples, L. A., . . . O'Donnell, C. J. (2016). Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies : The CHARGE Consortium. <em>PLoS ONE</em>, 11 (3), e0144997. <a href="http://dx.doi.org/10.1371/journal.pone.0144997">doi:10.1371/journal.pone.0144997</a>
dc.identifier.otherTUTKAID_69389
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/49079
dc.description.abstractBackground Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting. Methods We performed a two-stage GWAS analysis of incident myocardial infarction (MI) and CHD in a total of 64,297 individuals (including 3898 MI cases, 5465 CHD cases). SNPs that passed an arbitrary threshold of 5×10−6 in Stage I were taken to Stage II for further discovery. Furthermore, in an analysis of prognosis, we studied whether known SNPs from former GWAS were associated with total mortality in individuals who experienced MI during follow-up. Results In Stage I 15 loci passed the threshold of 5×10−6; 8 loci for MI and 8 loci for CHD, for which one locus overlapped and none were reported in previous GWAS meta-analyses. We took 60 SNPs representing these 15 loci to Stage II of discovery. Four SNPs near QKI showed nominally significant association with MI (p-value<8.8×10−3) and three exceeded the genome-wide significance threshold when Stage I and Stage II results were combined (top SNP rs6941513: p = 6.2×10−9). Despite excellent power, the 9p21 locus SNP (rs1333049) was only modestly associated with MI (HR = 1.09, p-value = 0.02) and marginally with CHD (HR = 1.06, p-value = 0.08). Among an inception cohort of those who experienced MI during follow-up, the risk allele of rs1333049 was associated with a decreased risk of subsequent mortality (HR = 0.90, p-value = 3.2×10−3). Conclusions QKI represents a novel locus that may serve as a predictor of incident CHD in prospective studies. The association of the 9p21 locus both with increased risk of first myocardial infarction and longer survival after MI highlights the importance of study design in investigating genetic determinants of complex disorders.
dc.language.isoeng
dc.publisherPublic Library of Science
dc.relation.ispartofseriesPLoS ONE
dc.rightsThis is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
dc.subject.otherincident myocardial infarction
dc.subject.othercoronary hearth disease
dc.titleGenome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies : The CHARGE Consortium
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201603091794
dc.contributor.laitosMatematiikan ja tilastotieteen laitosfi
dc.contributor.laitosDepartment of Mathematics and Statisticsen
dc.contributor.oppiaineTilastotiede
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-03-09T07:15:06Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn1932-6203
dc.relation.volume11
dc.type.versionpublishedVersion
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttps://creativecommons.org/publicdomain/zero/1.0/
dc.relation.doi10.1371/journal.pone.0144997


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This is an open access article, free of all
copyright, and may be freely reproduced, distributed,
transmitted, modified, built upon, or otherwise used
by anyone for any lawful purpose. The work is made
available under the Creative Commons CC0 public
domain dedication.
Except where otherwise noted, this item's license is described as This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.