Conformational properties and folding analysis of a series of seven oligoamide foldamers
Suhonen, A., Kortelainen, M., Nauha, E., Yliniemelä-Sipari, S., Pihko, P., & Nissinen, M. (2016). Conformational properties and folding analysis of a series of seven oligoamide foldamers. CrystEngComm, 18 (11), 2005-2013. doi:10.1039/C5CE02458G
© The Royal Society of Chemistry 2016. This is a final draft version of an article whose final and definitive form has been published by RSC. Published in this repository with the kind permission of the publisher.
33 crystal structures (11 unsolvated and 22 solvates) of a series of seven oligoamide foldamers were analysed. The crystal structures revealed that despite the structural and environmental differences the series of foldamers prefer only two general conformations, a protohelical @-conformation and a sigmoidal S-conformation. Both conformations also have preferred crystal packing motifs and solvate forming tendencies. Hydrogen bonding was found to be the most decisive factor in conformational preference, but steric properties, the type of the peripheral substituents, as well as solvent and aromatic interactions were also found to have an effect on the conformational details and crystal form.