Structural Tuning and Conformational Stability of Aromatic Oligoamide Foldamers
Annala, R., Suhonen, A., Laakkonen, H., Permi, P., & Nissinen, M. (2017). Structural Tuning and Conformational Stability of Aromatic Oligoamide Foldamers. Chemistry: A European Journal, 23(65), 16671-16680. https://doi.org/10.1002/chem.201703985
Published inChemistry: A European Journal
© 2017 Wiley-VCH Verlag GmbH & Co. This is a final draft version of an article whose final and definitive form has been published by Wiley. Published in this repository with the kind permission of the publisher.
A series of aromatic oligoamide foldamers with two or three pyridine-2,6-dicarboxamide units as their main folding motifs and varying aromatic building blocks as linkers have been synthetized to study the effects of the structural variation on the folding properties and conformational stability. Crystallographic studies showed that in the solid state the central linker unit either elongates the helices and more open S-shaped conformations, compresses the helices to more compact conformations or acts as a rigid spacer separating the pyridine-2,6-dicarboxamide units, which for their part add the predictability of the conformational properties. Multidimensional NMR studies showed that, even in solution, foldamers show conformational stability and folded conformations comparable to the solid state structures.