Exercise for bone and cartilage in postmenopausal women with mild knee osteoarthritis
Julkaistu sarjassa
Studies in sport, physical education and healthTekijät
Päivämäärä
2016Oppiaine
FysioterapiaThe purpose of this study was to investigate the effects of high-impact exercise
on bone mineral mass and strength, and on knee cartilage composition in
postmenopausal women with mild knee osteoarthritis (OA). In addition, the
association between knee OA and femoral neck bone structural characteristics
in women with mild knee radiographic OA and those without radiographic
knee OA was studied. Also, the reproducibility of measuring human knee joint
cartilage by the delayed gadolinium-enhanced MRI (dGEMRIC) technique was
determined in healthy asymptomatic subjects.
Data from a 12-month randomized controlled trial (RCT) was used to
assess the effects of exercise on bones and cartilages. The training intervention
comprised 80 postmenopausal women with mild knee OA. The primary
outcomes were bone mineral mass and strength, and the biochemical
composition of knee cartilage as assessed by quantitative MRI measures:
dGEMRIC and T2 relaxation time. Physical performance-related risk factors of
falling were also evaluated. Data assembled from an additional sample of
postmenopausal women with no knee symptoms (n = 12) and from the baseline
measures of the postmenopausal women with mild knee OA were used in the
cross-sectional association study. Prior to RCT, a test-retest study was
conducted in healthy subjects (n = 10) to assess the reproducibility of dGEMRIC.
The dGEMRIC technique showed good day-to-day reproducibility for the
different knee cartilage regions. In the association study, femoral neck bone
characteristics were significantly higher with higher grades in radiographic
knee OA, indicating an inverse relationship between OA and osteoporosis (OP).
The exercise program increased femoral neck bone mineral mass and strength.
Exercise also had positive effects on physical performance-related risk factors
for falls and exercise participation was well endured. However, the exercise had
no effect on knee cartilage composition. To conclude, progressively
implemented high-impact training is a safe and feasible exercise modality in the
prevention of OP and physical performance–related risk factors for falls in
postmenopausal women with mild knee OA.
...
Julkaisija
University of JyväskyläISBN
978-951-39-6564-8ISSN Hae Julkaisufoorumista
0356-1070Julkaisuun sisältyy osajulkaisuja
- Artikkeli I: Multanen J, Rauvala E, Lammentausta E, Ojala R, Kiviranta I, Häkkinen A, Nieminen MT, Heinonen A. Reproducibility of Imaging Human Knee Cartilage by Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC) at 1.5 Tesla. Osteoarthritis and Cartilage 2009;17:559-564. DOI:10.1016/j.joca.2008.12.001
- Artikkeli II: Multanen J, Heinonen A, Häkkinen A, Kautiainen H, Kujala U, Lammentausta E, Jämsä T, Kiviranta I, Nieminen MT. Bone and Cartilage Characteristics in Postmenopausal Women with Mild Knee Radiographic Osteoarthritis and Those without Radiographic Osteoarthritis. Journal of Musculoskeletal and Neuronal Interactions 2015; 15(1):69-77. Full text
- Artikkeli III: Multanen J, Nieminen MT, Häkkinen A, Kujala UM, Jämsä T, Kautiainen H, Lammentausta E, Ahola R, Selänne H, Ojala R, Kiviranta I, Heinonen A. Effects of High-Impact Training on Bone and Articular Cartilage: 12-Month Randomized Controlled Quantitative MRI Study. Journal of Bone and Mineral Research 2014;29(1):192-201. DOI:10.1002/jbmr.2015 .
- Artikkeli IV: Multanen J, Rantalainen T, Kautiainen H, Ahola R, Jämsä J, Nieminen MT, Lammentausta E, Häkkinen A, Kiviranta I, Heinonen A. Effect of Progressive High-Impact Exercise on Femoral Neck Structural Strength in Postmenopausal Women with Mild Knee Osteoarthritis: A 12-Month RCT. Submitted to Osteoporosis International.
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