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dc.contributor.authorMultanen, Juhani
dc.date.accessioned2016-03-01T09:53:40Z
dc.date.available2016-03-01T09:53:40Z
dc.date.issued2016
dc.identifier.isbn978-951-39-6564-8
dc.identifier.otheroai:jykdok.linneanet.fi:1523388
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/48974
dc.description.abstractThe purpose of this study was to investigate the effects of high-impact exercise on bone mineral mass and strength, and on knee cartilage composition in postmenopausal women with mild knee osteoarthritis (OA). In addition, the association between knee OA and femoral neck bone structural characteristics in women with mild knee radiographic OA and those without radiographic knee OA was studied. Also, the reproducibility of measuring human knee joint cartilage by the delayed gadolinium-enhanced MRI (dGEMRIC) technique was determined in healthy asymptomatic subjects. Data from a 12-month randomized controlled trial (RCT) was used to assess the effects of exercise on bones and cartilages. The training intervention comprised 80 postmenopausal women with mild knee OA. The primary outcomes were bone mineral mass and strength, and the biochemical composition of knee cartilage as assessed by quantitative MRI measures: dGEMRIC and T2 relaxation time. Physical performance-related risk factors of falling were also evaluated. Data assembled from an additional sample of postmenopausal women with no knee symptoms (n = 12) and from the baseline measures of the postmenopausal women with mild knee OA were used in the cross-sectional association study. Prior to RCT, a test-retest study was conducted in healthy subjects (n = 10) to assess the reproducibility of dGEMRIC. The dGEMRIC technique showed good day-to-day reproducibility for the different knee cartilage regions. In the association study, femoral neck bone characteristics were significantly higher with higher grades in radiographic knee OA, indicating an inverse relationship between OA and osteoporosis (OP). The exercise program increased femoral neck bone mineral mass and strength. Exercise also had positive effects on physical performance-related risk factors for falls and exercise participation was well endured. However, the exercise had no effect on knee cartilage composition. To conclude, progressively implemented high-impact training is a safe and feasible exercise modality in the prevention of OP and physical performance–related risk factors for falls in postmenopausal women with mild knee OA.
dc.format.extent1 verkkoaineisto (142, [74] sivua)
dc.language.isoeng
dc.publisherUniversity of Jyväskylä
dc.relation.ispartofseriesStudies in sport, physical education and health
dc.relation.haspart<b>Artikkeli I:</b> Multanen J, Rauvala E, Lammentausta E, Ojala R, Kiviranta I, Häkkinen A, Nieminen MT, Heinonen A. Reproducibility of Imaging Human Knee Cartilage by Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC) at 1.5 Tesla. <i>Osteoarthritis and Cartilage 2009;17:559-564. </i><a href=" http://dx.doi.org/ 10.1016/j.joca.2008.12.001 "target="_blank">DOI:10.1016/j.joca.2008.12.001 </a>
dc.relation.haspart<b>Artikkeli II:</b> Multanen J, Heinonen A, Häkkinen A, Kautiainen H, Kujala U, Lammentausta E, Jämsä T, Kiviranta I, Nieminen MT. Bone and Cartilage Characteristics in Postmenopausal Women with Mild Knee Radiographic Osteoarthritis and Those without Radiographic Osteoarthritis. <i>Journal of Musculoskeletal and Neuronal Interactions 2015; 15(1):69-77. </i><a href=" http://www.ismni.org/jmni/pdf/59/08MULTANEN.pdf "target="_blank"> Full text</a>
dc.relation.haspart<b>Artikkeli III:</b> Multanen J, Nieminen MT, Häkkinen A, Kujala UM, Jämsä T, Kautiainen H, Lammentausta E, Ahola R, Selänne H, Ojala R, Kiviranta I, Heinonen A. Effects of High-Impact Training on Bone and Articular Cartilage: 12-Month Randomized Controlled Quantitative MRI Study. <i>Journal of Bone and Mineral Research 2014;29(1):192-201</i><a href=" http://dx.doi.org/ 10.1002/jbmr.2015 "target="_blank">. DOI:10.1002/jbmr.2015 </a>.
dc.relation.haspart<b>Artikkeli IV:</b> Multanen J, Rantalainen T, Kautiainen H, Ahola R, Jämsä J, Nieminen MT, Lammentausta E, Häkkinen A, Kiviranta I, Heinonen A. Effect of Progressive High-Impact Exercise on Femoral Neck Structural Strength in Postmenopausal Women with Mild Knee Osteoarthritis: A 12-Month RCT. <i>Submitted to Osteoporosis International. </i>
dc.relation.isversionofJulkaistu myös painettuna.
dc.subject.otherexercise
dc.subject.otherosteoarthritis
dc.subject.otherpostmenopausal women
dc.subject.othercartilage
dc.subject.otherbone
dc.subject.otherknee
dc.subject.otherrandomized controlled trial
dc.titleExercise for bone and cartilage in postmenopausal women with mild knee osteoarthritis
dc.identifier.urnURN:ISBN:978-951-39-6564-8
dc.type.dcmitypeTexten
dc.type.ontasotVäitöskirjafi
dc.type.ontasotDoctoral dissertationen
dc.contributor.tiedekuntaLiikuntatieteellinen tiedekuntafi
dc.contributor.tiedekuntaFaculty of Sport and Health Sciencesen
dc.contributor.yliopistoUniversity of Jyväskyläen
dc.contributor.yliopistoJyväskylän yliopistofi
dc.contributor.oppiaineFysioterapiafi
dc.subject.methodSatunnaistetut kontrolloidut tutkimukset
dc.relation.issn0356-1070
dc.relation.numberinseries235
dc.rights.accesslevelopenAccessfi
dc.subject.ysonivelrikko
dc.subject.ysopolvet
dc.subject.ysonivelrusto
dc.subject.ysoliikunta
dc.subject.ysoharjoittelu
dc.subject.ysonaiset
dc.subject.ysotasannevuodet
dc.subject.ysoluuntiheys


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