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dc.contributor.authorCouppe, Christian
dc.contributor.authorSvensson, Rene Brüggebusch
dc.contributor.authorKongsgaard, Mads
dc.contributor.authorKovanen, Vuokko
dc.contributor.authorGrosset, Jean-Francois
dc.contributor.authorSnorgaard, Ole
dc.contributor.authorBencke, Jesper
dc.contributor.authorLarsen, Jytte Overgaard
dc.contributor.authorBandholm, Thomas
dc.contributor.authorChristensen, Tomas Møller
dc.contributor.authorBoesen, Anders Ploug
dc.contributor.authorHelmark, Ida C.
dc.contributor.authorAagaard, Per
dc.contributor.authorKjaer, Michael
dc.contributor.authorMagnusson, Stig Peter
dc.date.accessioned2016-02-19T11:58:42Z
dc.date.available2017-01-15T22:45:06Z
dc.date.issued2016
dc.identifier.citationCouppe, C., Svensson, R. B., Kongsgaard, M., Kovanen, V., Grosset, J.-F., Snorgaard, O., . . . Magnusson, S. P. (2016). Human Achilles tendon glycation and function in diabetes. <em>Journal of Applied Physiology</em>, 120 (2), 130-137. <a href="http://dx.doi.org/10.1152/japplphysiol.00547.2015">doi:10.1152/japplphysiol.00547.2015</a>
dc.identifier.otherTUTKAID_68530
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/48860
dc.description.abstractDiabetic patients have an increased risk of foot ulcers, and glycation of collagen may increase tissue stiffness. We hypothesized that the level of glycemic control (glycation) may affect Achilles tendon stiffness, which can influence gait pattern. We therefore investigated the relationship between collagen glycation, Achilles tendon stiffness parameters, and plantar pressure in poorly (n = 22) and well (n = 22) controlled diabetic patients, including healthy age-matched (45–70 yr) controls (n = 11). There were no differences in any of the outcome parameters (collagen cross-linking or tendon stiffness) between patients with well-controlled and poorly controlled diabetes. The overall effect of diabetes was explored by collapsing the diabetes groups (DB) compared with the controls. Skin collagen cross-linking lysylpyridinoline, hydroxylysylpyridinoline (136%, 80%, P < 0.01) and pentosidine concentrations (55%, P < 0.05) were markedly greater in DB. Furthermore, Achilles tendon material stiffness was higher in DB (54%, P < 0.01). Notably, DB also demonstrated higher forefoot/rearfoot peak-plantar-pressure ratio (33%, P < 0.01). Overall, Achilles tendon material stiffness and skin connective tissue cross-linking were greater in diabetic patients compared with controls. The higher foot pressure indicates that material stiffness of tendon and other tissue (e.g., skin and joint capsule) may influence foot gait. The difference in foot pressure distribution may contribute to the development of foot ulcers in diabetic patients.
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.relation.ispartofseriesJournal of Applied Physiology
dc.subject.otherdiabetes
dc.subject.otherenzymatic and non-enzymatic collagen cross-linking
dc.subject.otherAchilles tendon mechanics
dc.subject.otherfoot ulcer
dc.titleHuman Achilles tendon glycation and function in diabetes
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201602051460
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.contributor.oppiaineLiikuntalääketiede
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-02-05T10:15:02Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange130-137
dc.relation.issn8750-7587
dc.relation.volume120
dc.type.versionacceptedVersion
dc.rights.copyright© 2016 the American Physiological Society. This is a final draft version of an article whose final and definitive form has been published by APS. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.relation.doi10.1152/japplphysiol.00547.2015


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