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dc.contributor.authorKinnula, Hanna
dc.contributor.authorMappes, Johanna
dc.contributor.authorValkonen, Janne
dc.contributor.authorSundberg, Lotta-Riina
dc.date.accessioned2015-10-26T08:32:10Z
dc.date.available2015-10-26T08:32:10Z
dc.date.issued2015
dc.identifier.citationKinnula, H., Mappes, J., Valkonen, J., & Sundberg, L.-R. (2015). The Influence of Infective Dose on the Virulence of a Generalist Pathogen in Rainbow Trout (Oncorhynchus mykiss) and Zebra Fish (Danio rerio). <i>PLoS ONE</i>, <i>10</i>(9), Article e0139378. <a href="https://doi.org/10.1371/journal.pone.0139378" target="_blank">https://doi.org/10.1371/journal.pone.0139378</a>
dc.identifier.otherCONVID_25205609
dc.identifier.otherTUTKAID_67291
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/47400
dc.description.abstractPathogen density and genetic diversity fluctuate in the outside-host environment during and between epidemics, affecting disease emergence and the severity and probability of infections. Although the importance of these factors for pathogen virulence and infection probability has been acknowledged, their interactive effects are not well understood. We studied how an infective dose in an environmentally transmitted opportunistic fish pathogen, Flavobacterium columnare, affects its virulence both in rainbow trout, which are frequently infected at fish farms, and in zebra fish, a host that is not naturally infected by F. columnare. We used previously isolated strains of confirmed high and low virulence in a single infection and in a co-infection. Infection success (measured as host morbidity) correlated positively with dose when the hosts were exposed to the high-virulence strain, but no response for the dose increase was found when the hosts were exposed to the low-virulence strain. Interestingly, the co-infection resulted in poorer infection success than the single infection with the high-virulence strain. The rainbow trout were more susceptible to the infection than the zebra fish but, in both species, the effects of the doses and the strains were qualitatively similar. We suggest that as an increase in dose can lead to increased host morbidity, both the interstrain interactions and differences in infectivity in different hosts may influence the severity and consequently the evolution of disease. Our results also confirm that the zebra fish is a good laboratory model to study F. columnare infection.
dc.language.isoeng
dc.publisherPublic Library of Science
dc.relation.ispartofseriesPLoS ONE
dc.subject.otherpathogen
dc.titleThe Influence of Infective Dose on the Virulence of a Generalist Pathogen in Rainbow Trout (Oncorhynchus mykiss) and Zebra Fish (Danio rerio)
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201510083336
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineEcology and Evolutionary Biologyen
dc.contributor.oppiaineCell and Molecular Biologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2015-10-08T09:15:08Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn1932-6203
dc.relation.numberinseries9
dc.relation.volume10
dc.type.versionpublishedVersion
dc.rights.copyright© 2015 Kinnula et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
dc.rights.accesslevelopenAccessfi
dc.subject.ysokirjolohi
dc.subject.ysoseeprakala
dc.subject.ysobiologia
jyx.subject.urihttp://www.yso.fi/onto/yso/p12317
jyx.subject.urihttp://www.yso.fi/onto/yso/p22697
jyx.subject.urihttp://www.yso.fi/onto/yso/p1782
dc.rights.urlhttp://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1371/journal.pone.0139378


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© 2015 Kinnula et al. This is an open access article distributed under the terms of the
Creative Commons Attribution License.
Except where otherwise noted, this item's license is described as © 2015 Kinnula et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.