Projections onto the Pareto surface in multicriteria radiation therapy optimization
Bokrantz, R., & Miettinen, K. (2015). Projections onto the Pareto surface in multicriteria radiation therapy optimization. Medical Physics, 42(10), 5862-5870. https://doi.org/10.1118/1.4930252
Published inMedical Physics
© American Association of Physicists in Medicine 2015. This is a final draft version of an article whose final and definitive form has been published by American Association of Physicists in Medicine.
Purpose: To eliminate or reduce the error to Pareto optimality that arises in Pareto surface navigation when the Pareto surface is approximated by a small number of plans. Methods: The authors propose to project the navigated plan onto the Pareto surface as a postprocessing step to the navigation. The projection attempts to find a Pareto optimal plan that is at least as good as or better than the initial navigated plan with respect to all objective functions. An augmented form of projection is also suggested where dose–volume histogram constraints are used to prevent that the projection causes a violation of some clinical goal. The projections were evaluated with respect to planning for intensity modulated radiation therapy delivered by step-and-shoot and sliding window and spot-scanned intensity modulated proton therapy. Retrospective plans were generated for a prostate and a head and neck case. Results: The projections led to improved dose conformity and better sparing of organs at risk (OARs) for all three delivery techniques and both patient cases. The mean dose to OARs decreased by 3.1 Gy on average for the unconstrained form of the projection and by 2.0 Gy on average when dose–volume histogram constraints were used. No consistent improvements in target homogeneity were observed. Conclusions: There are situations when Pareto navigation leaves room for improvement in OAR sparing and dose conformity, for example, if the approximation of the Pareto surface is coarse or the problem formulation has too permissive constraints. A projection onto the Pareto surface can identify an inaccurate Pareto surface representation and, if necessary, improve the quality of the navigated plan. ...
PublisherAmerican Association of Physicists in Medicine
Publication in research information system
MetadataShow full item record
Showing items with similar title or keywords.
Paldanius, Hilkka (Kotikielen Seura, 2019)Artikkelissa selvitetään tiedonalakohtaisten tekstitaitojen viitekehyksessä, miten lukiolaisten historian esseissä rekontekstualisoidaan aineistona olevia historiallisia -dokumentteja ja miten dokumentteja selostavat ja ...
The Unseen, the Discouraged, and the Outcast : Expressivity and the Foundations of Social Recognition Taipale, Joona (De Gruyter, 2018)This article analyzes different pathologies of social affirmation and examines the grounds of social recognition from the point of view of the concept of expression. The red thread of the text is provided by Tove Jansson’s ...
Sindhya, Karthik; Ruuska, Sauli; Haanpää, Tomi; Miettinen, Kaisa (Springer, 2011)Differential evolution has become one of the most widely used evolution- ary algorithms in multiobjective optimization. Its linear mutation operator is a sim- ple and powerful mechanism to generate trial vectors. However, ...
A solution process for simulation-based multiobjective design optimization with an application in the paper industry Steponavice, Ingrida; Ruuska, Sauli; Miettinen, Kaisa (Elsevier, 2014)In this paper, we address some computational challenges arising in complex simulation-based design optimization problems. High computational cost, black-box formulation and stochasticity are some of the challenges related ...
Miettinen, Kaisa (Springer, 2014)When solving decision problems where multiple conflicting criteria are to be considered simultaneously, decision makers must compare several different alternatives and select the most preferred one. The task of comparing ...