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dc.contributor.authorViluksela, Matti
dc.contributor.authorHeikkinen, Päivi
dc.contributor.authorVen, Leo T. M. van der
dc.contributor.authorRendel, Filip
dc.contributor.authorRoos, Robert
dc.contributor.authorEsteban, Javier
dc.contributor.authorKorkalainen, Merja
dc.contributor.authorLensu, Sanna
dc.contributor.authorMiettinen, Hanna M.
dc.contributor.authorSavolainen, Kari
dc.contributor.authorSankari, Satu
dc.contributor.authorLilienthal, Hellmuth
dc.contributor.authorAdamsson, Annika
dc.contributor.authorToppari, Jorma
dc.contributor.authorHerlin, Maria
dc.contributor.authorFinnilä, Mikko
dc.contributor.authorTuukkanen, Juha
dc.contributor.authorLeslie, Heather A.
dc.contributor.authorHamers, Timo
dc.contributor.authorHamscher, Gerd
dc.contributor.authorAnati, Lauy Al-
dc.contributor.authorStenius, Ulla
dc.contributor.authorDervola, Kine-Susann
dc.contributor.authorBogen, Inger-Lise
dc.contributor.authorFonnum, Frode
dc.contributor.authorAndersson, Patrik L.
dc.contributor.authorSchrenk, Dieter
dc.contributor.authorHalldin, Krister
dc.contributor.authorHåkansson, Helen
dc.date.accessioned2014-09-01T07:05:54Z
dc.date.available2014-09-01T07:05:54Z
dc.date.issued2014fi
dc.identifier.citationViluksela, M., Heikkinen, P., Ven, L., Rendel, F., Roos, R., Esteban, J., . . . Håkansson, H. (2014). Toxicological Profile of Ultrapure 2,29,3,4,49,5,59- Heptachlorbiphenyl (PCB 180) in Adult Rats. <em>PLOS ONE</em>, 9 (8), e104639. <a href="http://dx.doi.org/10.1371/journal.pone.0104639">doi:10.1371/journal.pone.0104639</a>fi
dc.identifier.otherTUTKAID_62588
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/44141
dc.description.abstractAbstract: PCB 180 is a persistent non-dioxin-like polychlorinated biphenyl (NDL-PCB) abundantly present in food and the environment. Risk characterization of NDL-PCBs is confounded by the presence of highly potent dioxin-like impurities. We used ultrapure PCB 180 to characterize its toxicity profile in a 28-day repeat dose toxicity study in young adult rats extended to cover endocrine and behavioral effects. Using a loading dose/maintenance dose regimen, groups of 5 males and 5 females were given total doses of 0, 3, 10, 30, 100, 300, 1000 or 1700 mg PCB 180/kg body weight by gavage. Dose- responses were analyzed using benchmark dose modeling based on dose and adipose tissue PCB concentrations. Body weight gain was retarded at 1700 mg/kg during loading dosing, but recovered thereafter. The most sensitive endpoint of toxicity that was used for risk characterization was altered open field behavior in females; i.e. increased activity and distance moved in the inner zone of an open field suggesting altered emotional responses to unfamiliar environment and impaired behavioral inhibition. Other dose-dependent changes included decreased serum thyroid hormones with associated histopathological changes, altered tissue retinoid levels, decreased hematocrit and hemoglobin, decreased follicle stimulating hormone and luteinizing hormone levels in males and increased expression of DNA damage markers in liver of females. Dose-dependent hypertrophy of zona fasciculata cells was observed in adrenals suggesting activation of cortex. There were gender differences in sensitivity and toxicity profiles were partly different in males and females. PCB 180 adipose tissue concentrations were clearly above the general human population levels, but close to the levels in highly exposed populations. The results demonstrate a distinct toxicological profile of PCB 180 with lack of dioxin-like properties required for assignment of WHO toxic equivalency factor. However, PCB 180 shares several toxicological targets with dioxin-like compounds emphasizing the potential for interactions.fi
dc.language.isoeng
dc.publisherPublic Library of Science
dc.relation.ispartofseriesPLOS One
dc.relation.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0104639
dc.subject.othertoxicityfi
dc.subject.otherratsfi
dc.subject.otherthyroidfi
dc.subject.otherlipidfi
dc.titleToxicological Profile of Ultrapure 2,29,3,4,49,5,59- Heptachlorbiphenyl (PCB 180) in Adult Ratsfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201408272671
dc.contributor.laitosLiikuntabiologian laitosfi
dc.contributor.laitosDepartment of Biology of Physical Activityen
dc.contributor.oppiaineLiikuntafysiologia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2014-08-27T03:30:20Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn1932-6203
dc.relation.numberinseries8
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© 2014 Viluksela et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttp://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1371/journal.pone.0104639


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© 2014 Viluksela et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as © 2014 Viluksela et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.