Aerobic fitness does not modify the effect of FTO variation on body composition traits
Huuskonen, A., Lappalainen, J., Oksala, N., Santtila, M., Häkkinen, K., Kyröläinen, H., & Atalay, M. (2012). Aerobic fitness does not modify the effect of FTO variation on body composition traits. PLoS One, 7(12), e51635. https://doi.org/10.1371/journal.pone.0051635
Published inPLoS One
DisciplineLiikuntafysiologiaValmennus- ja testausoppiExercise PhysiologyScience of Sport Coaching and Fitness Testing
© 2012 Huuskonen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Purpose. Poor physical fitness and obesity are risk factors for all cause morbidity and mortality. We aimed to clarify whether common genetic variants of key energy intake determinants in leptin (LEP), leptin receptor (LEPR), and fat mass and obesity-associated (FTO) are associated with aerobic and neuromuscular performance, and whether aerobic fitness can alter the effect of these genotypes on body composition. Methods. 846 healthy Finnish males of Caucasian origin were genotyped for FTO (rs8050136), LEP (rs7799039) and LEPR (rs8179183 and rs1137101) single nucleotide polymorphisms (SNPs), and studied for associations with maximal oxygen consumption, body fat percent, serum leptin levels, waist circumference and maximal force of leg extensor muscles. Results. Genotype AA of the FTO SNP rs8050136 associated with higher BMI and greater waist circumference compared to the genotype CC. In general linear model, no significant interaction for FTO genotype-relative VO₂max (mL·kgˉ¹·minˉ¹) or FTO genotype-absolute VO₂max (L·minˉ¹) on BMI or waist circumference was found. Main effects of aerobic performance on body composition traits were significant (p<0.001). Logistic regression modelling found no significant interaction between aerobic fitness and FTO genotype. LEP SNP rs7799039, LEPR SNPs rs8179183 and rs1137101 did not associate with any of the measured variables, and no significant interactions of LEP or LEPR genotype with aerobic fitness were observed. In addition, none of the studied SNPs associated with aerobic or neuromuscular performance. Conclusions. Aerobic fitness may not modify the effect of FTO variation on body composition traits. However, relative aerobic capacity associates with lower BMI and waist circumference regardless of the FTO genotype. FTO, LEP and LEPR genotypes unlikely associate with physical performance. ...
PublisherPublic Library of Science
ISSN Search the Publication Forum1932-6203
Publication in research information system
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- Liikuntatieteiden tiedekunta 
Except where otherwise noted, this item's license is described as © 2012 Huuskonen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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