dc.contributor.author | von Bonsdorff, Mikaela | |
dc.contributor.author | Muller, Majon | |
dc.contributor.author | Aspelund, Thor | |
dc.contributor.author | Garcia, Melissa | |
dc.contributor.author | Eiriksdottir, Gudny | |
dc.contributor.author | Rantanen, Taina | |
dc.contributor.author | Gunnarsdottir, Ingibjorg | |
dc.contributor.author | Birgisdottir, Bryndis | |
dc.contributor.author | Thorsdottir, Inga | |
dc.contributor.author | Sigurdsson, Gunnar | |
dc.contributor.author | Gudnason, Vilmundur | |
dc.contributor.author | Launer, Lenore | |
dc.contributor.author | Harris, Tamara | |
dc.date.accessioned | 2013-12-11T09:40:59Z | |
dc.date.available | 2014-08-01T21:45:04Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | von Bonsdorff, M., Muller, M., Aspelund, T., Garcia, M., Eiriksdottir, G., Rantanen, T., Gunnarsdottir, I., Birgisdottir, B., Thorsdottir, I., Sigurdsson, G., Gudnason, V., Launer, L., & Harris, T. (2013). Persistence of the effect of birth size on dysglycaemia and type 2 diabetes in old age: AGES-Reykjavik Study. <i>AGE</i>, <i>35</i>(4), 1401-1409. <a href="https://doi.org/10.1007/s11357-012-9427-5" target="_blank">https://doi.org/10.1007/s11357-012-9427-5</a> | |
dc.identifier.other | CONVID_22472955 | |
dc.identifier.other | TUTKAID_56972 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/42640 | |
dc.description.abstract | We studied the effect of birth size on glucose and insulin metabolism among old non-diabetic individuals. We also explored the combined effect of birth size and midlife body mass index (BMI) on type 2 diabetes in old age. Our study comprised 1,682 Icelanders whose birth records included anthropometrical data. The same individuals had participated in the prospective population-based Reykjavik Study, where BMI was assessed at a mean age of 47 years, and in the AGES-Reykjavik Study during 2002 to 2006, where fasting glucose, insulin and HbA₁c were measured and homeostasis model assessment for the degree of insulin resistance (HOMA-IR) calculated at a mean age of 75.5 years. Type 2 diabetes was determined as having a history of diabetes, using glucose-modifying medication or fasting glucose of >7.0 mmol/l. Of the participants, 249 had prevalent type 2 diabetes in old age. Lower birth weight and body length were associated with higher fasting glucose, insulin, HOMA-IR and HbA₁c among old non-diabetic individuals. Higher birth weight and ponderal index at birth decreased the risk for type 2 diabetes in old age, odds ratio (OR), 0.61 [95 % confidence interval (CI), 0.48–0.79] and 0.96 (95 % CI, 0.92–1.00), respectively. Compared with those with high birth weight and low BMI in midlife, the odds of diabetes was almost five-fold for individuals with low birth weight and high BMI (OR, 4.93; 95 % CI, 2.14–11.37). Excessive weight gain in adulthood might be particularly detrimental to the health of old individuals with low birth weight. | fi |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation.ispartofseries | AGE | |
dc.subject.other | syntymäpaino | fi |
dc.subject.other | diabetes | fi |
dc.subject.other | ikääntyminen | fi |
dc.subject.other | birth size | |
dc.subject.other | aging | |
dc.title | Persistence of the effect of birth size on dysglycaemia and type 2 diabetes in old age: AGES-Reykjavik Study | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201312112773 | |
dc.contributor.laitos | Terveystieteiden laitos | fi |
dc.contributor.laitos | Department of Health Sciences | en |
dc.contributor.oppiaine | Gerontologia ja kansanterveys | fi |
dc.contributor.oppiaine | Gerontologian tutkimuskeskus | fi |
dc.contributor.oppiaine | Hyvinvoinnin tutkimuksen yhteisö | fi |
dc.contributor.oppiaine | Gerontology and Public Health | en |
dc.contributor.oppiaine | Gerontology Research Center | en |
dc.contributor.oppiaine | School of Wellbeing | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.date.updated | 2013-12-11T04:30:07Z | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 1401-1409 | |
dc.relation.issn | 0161-9152 | |
dc.relation.numberinseries | 4 | |
dc.relation.volume | 35 | |
dc.type.version | acceptedVersion | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | syntymäpaino | |
dc.subject.yso | diabetes | |
dc.subject.yso | ikääntyminen | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p21306 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p8304 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5056 | |
dc.relation.doi | 10.1007/s11357-012-9427-5 | |
dc.type.okm | A1 | |