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dc.contributor.authorvon Bonsdorff, Mikaela
dc.contributor.authorMuller, Majon
dc.contributor.authorAspelund, Thor
dc.contributor.authorGarcia, Melissa
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorRantanen, Taina
dc.contributor.authorGunnarsdottir, Ingibjorg
dc.contributor.authorBirgisdottir, Bryndis
dc.contributor.authorThorsdottir, Inga
dc.contributor.authorSigurdsson, Gunnar
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorLauner, Lenore
dc.contributor.authorHarris, Tamara
dc.date.accessioned2013-12-11T09:40:59Z
dc.date.available2014-08-01T21:45:04Z
dc.date.issued2013fi
dc.identifier.citationvon Bonsdorff, M., Muller, M., Aspelund, T., Garcia, M., Eiriksdottir, G., Rantanen, T., Gunnarsdottir, I., Birgisdottir, B., Thorsdottir, I., Sigurdsson, G., Gudnason, V., Launer, L. & Harris, T. (2013). Persistence of the effect of birth size on dysglycaemia and type 2 diabetes in old age: AGES-Reykjavik Study. AGE, 35 (4), 1401-1409. doi:10.1007/s11357-012-9427-5fi
dc.identifier.otherTUTKAID_56972
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/42640
dc.description.abstractWe studied the effect of birth size on glucose and insulin metabolism among old non-diabetic individuals. We also explored the combined effect of birth size and midlife body mass index (BMI) on type 2 diabetes in old age. Our study comprised 1,682 Icelanders whose birth records included anthropometrical data. The same individuals had participated in the prospective population-based Reykjavik Study, where BMI was assessed at a mean age of 47 years, and in the AGES-Reykjavik Study during 2002 to 2006, where fasting glucose, insulin and HbA₁c were measured and homeostasis model assessment for the degree of insulin resistance (HOMA-IR) calculated at a mean age of 75.5 years. Type 2 diabetes was determined as having a history of diabetes, using glucose-modifying medication or fasting glucose of >7.0 mmol/l. Of the participants, 249 had prevalent type 2 diabetes in old age. Lower birth weight and body length were associated with higher fasting glucose, insulin, HOMA-IR and HbA₁c among old non-diabetic individuals. Higher birth weight and ponderal index at birth decreased the risk for type 2 diabetes in old age, odds ratio (OR), 0.61 [95 % confidence interval (CI), 0.48–0.79] and 0.96 (95 % CI, 0.92–1.00), respectively. Compared with those with high birth weight and low BMI in midlife, the odds of diabetes was almost five-fold for individuals with low birth weight and high BMI (OR, 4.93; 95 % CI, 2.14–11.37). Excessive weight gain in adulthood might be particularly detrimental to the health of old individuals with low birth weight.fi
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesAGE
dc.subject.othersyntymäpainofi
dc.subject.otherdiabetesfi
dc.subject.otherikääntyminenfi
dc.subject.otherbirth size
dc.subject.otheraging
dc.titlePersistence of the effect of birth size on dysglycaemia and type 2 diabetes in old age: AGES-Reykjavik Studyfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201312112773
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.type.urihttp://purl.org/eprint/type/SubmittedJournalArticle
dc.date.updated2013-12-11T04:30:07Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1401-1409
dc.relation.issn0161-9152
dc.relation.numberinseries4
dc.relation.volume35
dc.type.versionacceptedVersion
dc.rights.accesslevelopenAccessfi
dc.relation.doi10.1007/s11357-012-9427-5


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