Packing incentives and a reliable N–H···N pyridine synthon in co-crystallization of bipyridines with two agrochemical actives
Nauha, E., Kolehmainen, E., & Nissinen, M. (2011). Packing incentives and a reliable N–H...N–pyridine synthon in co-crystallization of bipyridines with two agrochemical actives. CrystEngComm, 13 (21), 6531-6537. doi:10.1039/C1CE05730H
© The Royal Society of Chemistry 2011. This is an electronic final draft version of an article whose final and definitive form has been published in CrystEngComm by RSC.
The co-crystallization of agrochemical actives thiophanate-methyl and thiophanate-ethyl with 2,2′-bipyridine, 4,4′-bipyridine and 1,2-bis(4-pyridyl)ethane was investigated with conventional crystallization, the slurry method and liquid-assisted grinding. Co-crystals of both thiophanates with all bipyridines were found and the structures solved with single crystal X-ray diffraction. Whereas the 2,2′-bipyridine co-crystals seem to form because of a combination of weak interactions, and in the case of the thiophanate-methyl, partly because of close packing incentives, the 4,4′-bipyridine and 1,2-bis(4-pyridyl)ethane co-crystals form mainly because of a favourable N–H···N–pyridine hydrogen bonding synthon.