Showing items with similar title or keywords.

• Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism 

  Ylilauri, Mikko; Pentikäinen, Olli (Public Library of Science, 2012)

  N-methyl-D-aspartate (NMDA) receptors belong to a family of ionotropic glutamate receptors that contribute to the signal transmission in the central nervous system. NMDA receptors are heterotetramers that usually consist ...

• Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation 

  Cisterna, Bruno A.; Vargas, Aníbal A.; Puebla, Carlos; Fernández, Paola; Escamilla, Rosalba; Lagos, Carlos F.; Matus, María F.; Vilos, Cristian; Cea, Luis A.; Barnafi, Esteban; Gaete, Hugo; Escobar, Daniel F.; Cardozo, Christopher P.; Sáez, Juan C. (Nature Publishing Group, 2020)

  Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased plasma membrane permeability, reduced resting membrane potential and accelerated protein catabolism. ...

• Exploring kainate receptor pharmacology using molecular dynamics simulations 

  Postila, Pekka; Swanson, Geoffrey; Pentikäinen, Olli (2010)

  Ionotropic glutamate receptors (iGluRs) are enticing targets for pharmaceutical research; however, the search for selective ligands is a laborious experimental process. Here we introduce a purely computational procedure ...

• Effect of ligand-binding on protein function 

  Ylilauri, Mikko (University of Jyväskylä, 2014)

• Computational approach to design of aptamers to the receptor binding domain of SARS-CoV-2 

  Artyushenko, P. V.; Mironov, V. A.; Morozov, D. I.; Shchugoreva, I. A.; Borbone, N.; Tomilin, F. N.; Kichkailo, A. S. (Krasnoyarsk State Medical University, 2021)

  The aim of the research. In this work, in silico selection of DNA-aptamers to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein was performed using molecular modeling methods. Material and methods. A ...