Showing items with similar title or keywords.

• Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation 

  Cisterna, Bruno A.; Vargas, Aníbal A.; Puebla, Carlos; Fernández, Paola; Escamilla, Rosalba; Lagos, Carlos F.; Matus, María F.; Vilos, Cristian; Cea, Luis A.; Barnafi, Esteban; Gaete, Hugo; Escobar, Daniel F.; Cardozo, Christopher P.; Sáez, Juan C. (Nature Publishing Group, 2020)

  Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased plasma membrane permeability, reduced resting membrane potential and accelerated protein catabolism. ...

• Exploring kainate receptor pharmacology using molecular dynamics simulations 

  Postila, Pekka; Swanson, Geoffrey; Pentikäinen, Olli (2010)

  Ionotropic glutamate receptors (iGluRs) are enticing targets for pharmaceutical research; however, the search for selective ligands is a laborious experimental process. Here we introduce a purely computational procedure ...

• Effect of ligand-binding on protein function 

  Ylilauri, Mikko (University of Jyväskylä, 2014)

• Blocking Activin Receptor Ligands Is Not Sufficient to Rescue Cancer-Associated Gut Microbiota : A Role for Gut Microbial Flagellin in Colorectal Cancer and Cachexia? 

  Pekkala, Satu; Keskitalo, Anniina; Kettunen, Emilia; Lensu, Sanna; Nykänen, Noora; Kuopio, Teijo; Ritvos, Olli; Hentilä, Jaakko; Nissinen, Tuuli A.; Hulmi, Juha J. (MDPI AG, 2019)

  Colorectal cancer (CRC) and cachexia are associated with the gut microbiota and microbial surface molecules. We characterized the CRC-associated microbiota and investigated whether cachexia affects the microbiota composition. ...

• Negatively Charged Gangliosides Promote Membrane Association of Amphipathic Neurotransmitters 

  Juhola, Hanna; Postila, Pekka; Rissanen, Sami; Lolicato, Fabio; Vattulainen, Ilpo; Róg, Tomasz (Pergamon Press, 2018)

  Lipophilic neurotransmitters (NTs) such as dopamine are chemical messengers enabling neurotransmission by adhering onto the extracellular surface of the post-synaptic membrane in a synapse, followed by binding to their ...