Showing items with similar title or keywords.

• Effect of ligand-binding on protein function 

  Ylilauri, Mikko (University of Jyväskylä, 2014)

• Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism 

  Ylilauri, Mikko; Pentikäinen, Olli (PLOS, 2012)

  N-methyl-D-aspartate (NMDA) receptors belong to a family of ionotropic glutamate receptors that contribute to the signal transmission in the central nervous system. NMDA receptors are heterotetramers that usually consist ...

• Rational drug discovery : structural studies of protein-ligand complexes 

  Nurminen, Elisa (University of Jyväskylä, 2011)

• Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation 

  Cisterna, Bruno A.; Vargas, Aníbal A.; Puebla, Carlos; Fernández, Paola; Escamilla, Rosalba; Lagos, Carlos F.; Matus, María F.; Vilos, Cristian; Cea, Luis A.; Barnafi, Esteban; Gaete, Hugo; Escobar, Daniel F.; Cardozo, Christopher P.; Sáez, Juan C. (Nature Publishing Group, 2020)

  Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased plasma membrane permeability, reduced resting membrane potential and accelerated protein catabolism. ...

• Exploring kainate receptor pharmacology using molecular dynamics simulations 

  Postila, Pekka; Swanson, Geoffrey; Pentikäinen, Olli (2010)

  Ionotropic glutamate receptors (iGluRs) are enticing targets for pharmaceutical research; however, the search for selective ligands is a laborious experimental process. Here we introduce a purely computational procedure ...