Fecal pancreatic elastase-1 levels in older individuals without known gastrointestinal diseases or diabetes mellitus

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dc.contributor.author Herzig, Karl-Heinz
dc.contributor.author Purhonen, Anna-Kaisa
dc.contributor.author Räsänen, Kati
dc.contributor.author Idziak, Joanna
dc.contributor.author Juvonen, Petri
dc.contributor.author Phillps, Ryszard
dc.contributor.author Walkowiak, Jaroslaw
dc.date.accessioned 2012-02-17T08:32:08Z
dc.date.available 2012-02-17T08:32:08Z
dc.date.issued 2011
dc.identifier.citation Herzig, K., Purhonen, A., Räsänen, K., Idziak, J., Juvonen, P., Phillps, R., & Walkowiak, J. (2011). Fecal pancreatic elastase-1 levels in older individuals without known gastrointestinal diseases or diabetes mellitus. BMC Geriatrics, 11 (4). doi:10.1186/1471-2318-11-4
dc.identifier.issn 1471-2318
dc.identifier.uri http://hdl.handle.net/123456789/37395
dc.description.abstract Background - Structural changes occur in the pancreas as a part of the natural aging process. With aging, also the incidence of maldigestive symptoms and malnutrition increases, raising the possibility that these might be caused at least in part by inadequate pancreatic enzyme secretion due to degenerative processes and damage of the gland. Fecal elastase-1 is a good marker of pancreatic exocrine secretion. The aim of this study was to investigate the fecal elastase-1 levels among over 60 years old Finnish and Polish healthy individuals without any special diet, known gastrointestinal disease, surgery or diabetes mellitus. Methods - A total of 159 patients participated in this cross-sectional study. 106 older individuals (aged 60-92 years) were recruited from outpatient clinics and elderly homes. They were divided to three age groups: 60-69 years old (n = 31); 70-79 years old (n = 38) and over 80 years old (n = 37). 53 young subjects (20-28 years old) were investigated as controls. Inclusion criteria were age over 60 years, normal status and competence. Exclusion criteria were any special diet, diabetes mellitus, any known gastrointestinal disease or prior gastrointestinal surgery. Fecal elastase-1 concentration was measured from stool samples with an ELISA that uses two monoclonal antibodies against different epitopes of human elastase-1. Results - Fecal elastase-1 concentrations correlated negatively with age (Pearson r = -0,3531, P < 0.001) and were significantly lower among subjects over 70 years old compared to controls (controls vs. 70-79 years old and controls vs. over 80 years old, both P < 0.001). Among the over 60 years old subjects, the fecal elastase-1 concentrations were below the cut off level of 200 μg/g in 23 of 106 (21.7%) individuals [mean 112 (86-138) μg/g] indicating pancreatic exocrine insufficiency. Of those, 9 subjects had fecal elastase-1 level below 100 μg/g as a marker of severe pancreatic insufficiency. Conclusion - In our study one fifth of healthy older individuals without any gastrointestinal disorder, surgery or diabetes mellitus suffer from pancreatic exocrine insufficiency and might benefit from enzyme supplementation therapy. fi
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Geriatrics
dc.relation.uri http://www.biomedcentral.com/bmcgeriatr
dc.rights © 2011 Herzig et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/2.0
dc.subject.other vanhukset fi
dc.subject.other haima fi
dc.subject.other vajaatoiminta fi
dc.subject.other fekaalinen elastaasi-1 fi
dc.subject.other elderly en
dc.subject.other pancreas en
dc.subject.other insufficiency en
dc.subject.other fecal elastase-1 en
dc.title Fecal pancreatic elastase-1 levels in older individuals without known gastrointestinal diseases or diabetes mellitus
dc.type Article en
dc.identifier.urn URN:NBN:fi:jyu-201202171202
dc.subject.kota 118
dc.contributor.laitos Bio- ja ympäristötieteiden laitos fi
dc.contributor.laitos Department of Biological and Environmental Science en
dc.type.uri http://purl.org/eprint/type/JournalArticle
dc.identifier.doi doi:10.1186/1471-2318-11-4
dc.description.version Publisher's version
eprint.status http://purl.org/eprint/type/status/PeerReviewed

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