Predation on Multiple Trophic Levels Shapes the Evolution of Pathogen Virulence

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dc.contributor.author Friman, Ville-Petri
dc.contributor.author Lindstedt, Carita
dc.contributor.author Laakso, Jouni
dc.contributor.author Mappes, Johanna
dc.date.accessioned 2011-05-12T07:30:48Z
dc.date.available 2011-05-12T07:30:48Z
dc.date.issued 2009
dc.identifier.citation Friman, V.-P., Lindstedt, C., Hiltunen, T., Laakso, J. & Mappes, J. (2009). Predation on multiple trophic levels shapes the evolution of pathogen virulence. PLoS ONE, 4 (8), e6761.
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/123456789/26946
dc.description.abstract The pathogen virulence is traditionally thought to co-evolve as a result of reciprocal selection with its host organism. In natural communities, pathogens and hosts are typically embedded within a web of interactions with other species, which could affect indirectly the pathogen virulence and host immunity through trade-offs. Here we show that selection by predation can affect both pathogen virulence and host immune defence. Exposing opportunistic bacterial pathogen Serratia marcescens to predation by protozoan Tetrahymena thermophila decreased its virulence when measured as host moth Parasemia plantaginis survival. This was probably because the bacterial anti-predatory traits were traded off with bacterial virulence factors, such as motility or resource use efficiency. However, the host survival depended also on its allocation to warning signal that is used against avian predation. When infected with most virulent ancestral bacterial strain, host larvae with a small warning signal survived better than those with an effective large signal. This suggests that larval immune defence could be traded off with effective defence against bird predators. However, the signal size had no effect on larval survival when less virulent control or evolved strains were used for infection suggesting that anti-predatory defence against avian predators, might be less constrained when the invading pathogen is rather low in virulence. Our results demonstrate that predation can be important indirect driver of the evolution of both pathogen virulence and host immunity in communities with multiple species interactions. Thus, the pathogen virulence should be viewed as a result of both past evolutionary history, and current ecological interactions. en
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights © 2009 Friman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri
dc.subject.other evoluutio fi
dc.subject.other peto-saalissuhde fi
dc.subject.other virulenssi fi
dc.subject.other immuniteetti fi
dc.subject.other allokaatiokustannus fi
dc.subject.other Serratia marcescens en
dc.subject.other Tetrahymena thermophila en
dc.subject.other Parasemia plantaginis en
dc.title Predation on Multiple Trophic Levels Shapes the Evolution of Pathogen Virulence
dc.type Article en
dc.identifier.urn URN:NBN:fi:jyu-2011051210787
dc.subject.kota 118
dc.contributor.laitos Bio- ja ympäristötieteiden laitos fi
dc.contributor.laitos Department of Biological and Environmental Science en
dc.type.uri http://purl.org/eprint/type/JournalArticle
dc.identifier.doi doi:10.1371/journal.pone.0006761
dc.description.version Published PDF
eprint.status http://purl.org/eprint/type/status/PeerReviewed

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