Eight-year diet and physical activity intervention affects serum metabolites during childhood and adolescence : A nonrandomized controlled trial
Zarei, I., Eloranta, A.-M., Klåvus, A., Väistö, J., Lehtonen, M., Mikkonen, S., Koistinen, V. M., Sallinen, T., Haapala, E. A., Lintu, N., Soininen, S., Haikonen, R., Atalay, M., Schwab, U., Auriola, S., Kolehmainen, M., Hanhineva, K., & Lakka, T. A. (2024). Eight-year diet and physical activity intervention affects serum metabolites during childhood and adolescence : A nonrandomized controlled trial. iScience, 27(7), Article 110295. https://doi.org/10.1016/j.isci.2024.110295
Julkaistu sarjassa
iScienceTekijät
Päivämäärä
2024Tekijänoikeudet
© 2024 the Authors
Long-term lifestyle interventions in childhood and adolescence can significantly improve cardiometabolic health, but the underlying molecular mechanisms remain poorly understood. To address this knowledge gap, we conducted an 8-year diet and physical activity intervention in a general population of children. The research revealed that the intervention influenced 80 serum metabolites over two years, with 17 metabolites continuing to be affected after eight years. The intervention primarily impacted fatty amides, including palmitic amide, linoleamide, oleamide, and others, as well as unsaturated fatty acids, acylcarnitines, phospholipids, sterols, gut microbiota-derived metabolites, amino acids, and purine metabolites. Particularly noteworthy were the pronounced changes in serum fatty amides. These serum metabolite alterations could represent molecular mechanisms responsible for the observed benefits of long-term lifestyle interventions on cardiometabolic and overall health since childhood. Understanding these metabolic changes may provide valuable insights into the prevention of cardiometabolic and other non-communicable diseases since childhood.
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Julkaisija
Cell PressISSN Hae Julkaisufoorumista
2589-0042Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/220781366
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The PANIC study has been supported financially by grants from the Academy of Finland, the Ministry of Education and Culture of Finland, the Ministry of Social Affairs and Health of Finland, the Research Committee of the Kuopio University Hospital Catchment Area (State Research Funding), Finnish Innovation Fund Sitra, Social Insurance Institution of Finland, Finnish Cultural Foundation, Foundation for Pediatric Research, Diabetes Research Foundation in Finland, Finnish Foundation for Cardiovascular Research, Juho Vainio Foundation, Paavo Nurmi Foundation, Yrjö Jahnsson Foundation, and the city of Kuopio. Moreover, the current work was supported by the Horizon 2020 research and innovation programme of European Union (Grant 874739 for the LongITools project, including the research groups of MK, TAL, and KH). ...Lisenssi
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The effects of an exercise intervention on neuroelectric activity and executive function in children with overweight/obesity : The ActiveBrains randomized controlled trial
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