dc.contributor.author | Föhr, Tiina | |
dc.contributor.author | Hendrix, Arne | |
dc.contributor.author | Kankaanpää, Anna | |
dc.contributor.author | Laakkonen, Eija K. | |
dc.contributor.author | Kujala, Urho | |
dc.contributor.author | Pietiläinen, Kirsi H. | |
dc.contributor.author | Lehtimäki, Terho | |
dc.contributor.author | Kähönen, Mika | |
dc.contributor.author | Raitakari, Olli | |
dc.contributor.author | Wang, Xiaoling | |
dc.contributor.author | Kaprio, Jaakko | |
dc.contributor.author | Ollikainen, Miina | |
dc.contributor.author | Sillanpää, Elina | |
dc.date.accessioned | 2024-02-01T12:38:00Z | |
dc.date.available | 2024-02-01T12:38:00Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Föhr, T., Hendrix, A., Kankaanpää, A., Laakkonen, E. K., Kujala, U., Pietiläinen, K. H., Lehtimäki, T., Kähönen, M., Raitakari, O., Wang, X., Kaprio, J., Ollikainen, M., & Sillanpää, E. (2024). Metabolic syndrome and epigenetic aging : a twin study. <i>International Journal of Obesity</i>, <i>Early online</i>. <a href="https://doi.org/10.1038/s41366-024-01466-x" target="_blank">https://doi.org/10.1038/s41366-024-01466-x</a> | |
dc.identifier.other | CONVID_202788093 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/93208 | |
dc.description.abstract | Background
Metabolic syndrome (MetS) is associated with premature aging, but whether this association is driven by genetic or lifestyle factors remains unclear.
Methods
Two independent discovery cohorts, consisting of twins and unrelated individuals, were examined (N = 268, aged 23–69 years). The findings were replicated in two cohorts from the same base population. One consisted of unrelated individuals (N = 1 564), and the other of twins (N = 293). Participants’ epigenetic age, estimated using blood DNA methylation data, was determined using the epigenetic clocks GrimAge and DunedinPACE. The individual-level linear regression models for investigating the associations of MetS and its components with epigenetic aging were followed by within-twin-pair analyses using fixed-effects regression models to account for genetic factors.
Results
In individual-level analyses, GrimAge age acceleration was higher among participants with MetS (N = 56) compared to participants without MetS (N = 212) (mean 2.078 [95% CI = 0.996,3.160] years vs. −0.549 [−1.053,−0.045] years, between-group p = 3.5E-5). Likewise, the DunedinPACE estimate was higher among the participants with MetS compared to the participants without MetS (1.032 [1.002,1.063] years/calendar year vs. 0.911 [0.896,0.927] years/calendar year, p = 4.8E-11). An adverse profile in terms of specific MetS components was associated with accelerated aging. However, adjustments for lifestyle attenuated these associations; nevertheless, for DunedinPACE, they remained statistically significant. The within-twin-pair analyses suggested that genetics explains these associations fully for GrimAge and partly for DunedinPACE. The replication analyses provided additional evidence that the association between MetS components and accelerated aging is independent of the lifestyle factors considered in this study, however, suggesting that genetics is a significant confounder in this association.
Conclusions
The results of this study suggests that MetS is associated with accelerated epigenetic aging, independent of physical activity, smoking or alcohol consumption, and that the association may be explained by genetics. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group | |
dc.relation.ispartofseries | International Journal of Obesity | |
dc.rights | CC BY 4.0 | |
dc.subject.other | epigeneettinen ikääntyminen | |
dc.subject.other | genetics | |
dc.subject.other | signs and symptoms | |
dc.subject.other | epigenetic aging | |
dc.title | Metabolic syndrome and epigenetic aging : a twin study | |
dc.type | research article | |
dc.identifier.urn | URN:NBN:fi:jyu-202402011716 | |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.contributor.oppiaine | Gerontologia ja kansanterveys | fi |
dc.contributor.oppiaine | Liikuntalääketiede | fi |
dc.contributor.oppiaine | Hyvinvoinnin tutkimuksen yhteisö | fi |
dc.contributor.oppiaine | Fyysinen aktiivisuus eliniän aikana | fi |
dc.contributor.oppiaine | Gerontology and Public Health | en |
dc.contributor.oppiaine | Sports and Exercise Medicine | en |
dc.contributor.oppiaine | School of Wellbeing | en |
dc.contributor.oppiaine | Physical activity through life span | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.relation.issn | 0307-0565 | |
dc.relation.volume | Early online | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © 2024 the Authors | |
dc.rights.accesslevel | openAccess | fi |
dc.type.publication | article | |
dc.relation.grantnumber | 346509 | |
dc.relation.grantnumber | 275323 | |
dc.relation.grantnumber | 330281 | |
dc.relation.grantnumber | 326242 | |
dc.relation.grantnumber | 341750 | |
dc.subject.yso | ikä | |
dc.subject.yso | kaksostutkimus | |
dc.subject.yso | elintavat | |
dc.subject.yso | perimä | |
dc.subject.yso | vanheneminen | |
dc.subject.yso | aineenvaihdunta | |
dc.subject.yso | metabolinen oireyhtymä | |
dc.subject.yso | epigenetiikka | |
dc.subject.yso | ympäristötekijät | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p1229 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p18525 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5530 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p8862 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p470 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p3066 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p6238 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p24631 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p6194 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1038/s41366-024-01466-x | |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
jyx.fundingprogram | Akatemiatutkijan tutkimuskulut, SA | fi |
jyx.fundingprogram | Akatemiahanke, SA | fi |
jyx.fundingprogram | Akatemiahanke, SA | fi |
jyx.fundingprogram | Profilointi, SA | fi |
jyx.fundingprogram | Akatemiatutkija, SA | fi |
jyx.fundingprogram | Research costs of Academy Research Fellow, AoF | en |
jyx.fundingprogram | Academy Project, AoF | en |
jyx.fundingprogram | Academy Project, AoF | en |
jyx.fundingprogram | Research profiles, AoF | en |
jyx.fundingprogram | Academy Research Fellow, AoF | en |
jyx.fundinginformation | TF is supported by the Juho Vainio Foundation and the Yrjö Jahnsson Foundation. ES is supported by the Academy of Finland (grant numbers 341750, 346509, 260001), the Juho Vainio Foundation, the Päivikki and Sakari Sohlberg Foundation, and the Yrjö Jahnsson Foundation (6168). JK is supported by the Academy of Finland (grant numbers 213506, 308248, 312073, 336823), EC FP5 GenomEUtwin, NIH NIH/NHLBI (grant HL104125), EC MC ITN Project EPITRAIN, and the Sigrid Juselius Foundation. MO is supported by the Academy of Finland (grant numbers 328685, 307339, 297908 and 251316), EC MC ITN Project EPITRAIN, University of Helsinki Research Funds, and the Sigrid Juselius Foundation. KHP is supported by the Academy of Finland (grant numbers 272376, 266286, 314383, 335443), Finnish Medical Foundation, Finnish Diabetes Research Foundation, Novo Nordisk Foundation (NNF10OC1013354, NNF17OC0027232, NNF20OC0060547), Signe and Ane Gyllenberg Foundation, Sigrid Juselius Foundation, Government Research Funds for Helsinki University Hospital Research Funds, and the University of Helsinki. EKL was supported by the Academy of Finland (grant numbers 275323 and 330281) and the PACTS2 profiling action of the University of Jyväskylä funded by the Academy of Finland (326242). The Gerontology Research Center is a joint effort between the University of Jyväskylä and the University of Tampere. The YFS has been financially supported by the following sources: Academy of Finland (grant numbers 356405, 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 255381, 256474, 283115, 319060, 320297, 314389, 338395, 330809, and 104821, 129378 (Salve), 117797 (Gendi), and 141071 (Skidi)); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility Area of Kuopio, Tampere and Turku University Hospitals (grant X51001); the Juho Vainio Foundation; the Paavo Nurmi Foundation; the Finnish Foundation for Cardiovascular Research; the Finnish Cultural Foundation; the Sigrid Juselius Foundation; the Tampere Tuberculosis Foundation; the Emil Aaltonen Foundation; the Yrjö Jahnsson Foundation; the Signe and Ane Gyllenberg Foundation; the Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (grant 755320 for TAXINOMISIS and grant 848146 for To Aition); the European Research Council (grant 742927 for MULTIEPIGEN project); the Tampere University Hospital Supporting Foundation, Finnish Society of Clinical Chemistry; the Cancer Foundation Finland; pBETTER4U_EU (Preventing obesity through Biologically and bEhaviorally Tailored inTERventions for you; project number: 101080117); and the Jane and Aatos Erkko Foundation. The EH-Epi has been finally supported by the NIH/NHLBI grant HL104125. Open Access funding provided by University of Jyväskylä (JYU). | |
dc.type.okm | A1 | |