A Novel Na(I) Coordination Complex with s-Triazine Pincer Ligand : Synthesis, X-ray Structure, Hirshfeld Analysis, and Antimicrobial Activity
Yousri, A., El-Faham, A., Haukka, M., Ayoup, M. S., Ismail, M. M. F., El Menofy, N. G., Soliman, S. M., Öhrström, L., Barakat, A., & Abu-Youssef, M. A. M. (2023). A Novel Na(I) Coordination Complex with s-Triazine Pincer Ligand : Synthesis, X-ray Structure, Hirshfeld Analysis, and Antimicrobial Activity. Crystals, 13(6), Article 890. https://doi.org/10.3390/cryst13060890
Julkaistu sarjassa
CrystalsTekijät
Päivämäärä
2023Oppiaine
Epäorgaaninen kemiaEpäorgaaninen ja analyyttinen kemiaInorganic ChemistryInorganic and Analytical ChemistryTekijänoikeudet
© 2023 by the authors. Licensee MDPI, Basel, Switzerland
The pincer ligand 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (bpmt) was used to synthesize the novel [Na(bpmt)2][AuCl4] complex through the self-assembly method. In this complex, the Na(I) ion is hexa-coordinated with two tridentate N-pincer ligands (bpmt). The two bpmt ligand units are meridionally coordinated to Na(I) via one short Na-N(s-triazine) and two slightly longer Na-N(pyrazole) bonds, resulting in a distorted octahedral geometry around the Na(I) ion. In the coordinated bpmt ligand, the s-triazine core is not found to be coplanar with the two pyrazole moieties. Additionally, the two bpmt units are strongly twisted from one another by 64.94°. Based on Hirshfeld investigations, the H···H (53.4%) interactions have a significant role in controlling the supramolecular arrangement of the [Na(bpmt)2][AuCl4] complex. In addition, the Cl···H (12.2%), C···H (11.5%), N···H (9.3%), and O···H (4.9%) interactions are significant. Antimicrobial investigations revealed that the [Na(bpmt)2][AuCl4] complex has promising antibacterial and antifungal activities. The [Na(bpmt)2][AuCl4] complex showed enhanced antibacterial activity for the majority of the studied gram-positive and gram-negative bacteria compared to the free bpmt (MIC = 62.5–125 µg/mL vs. MIC = 62.5–500 µg/mL, respectively) and Amoxicillin (MIC > 500 µg/mL) as a positive control. Additionally, the [Na(bpmt)2][AuCl4] complex had better antifungal efficacy (MIC = 125 µg/mL) against C. albicans compared to bpmt (MIC = 500 µg/mL).
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2073-4352Asiasanat
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https://converis.jyu.fi/converis/portal/detail/Publication/183355298
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The authors would like to extend their sincere appreciation to the Researchers Supporting Project (RSP2023R64), King Saud University, Riyadh, Saudi Arabia.Lisenssi
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