Self-reported life-space mobility in the first year after ischemic stroke : longitudinal findings from the MOBITEC-Stroke project
Hinrichs, T., Rössler, R., Infanger, D., Weibel, R., Schär, J., Peters, E.-M., Portegijs, E., Rantanen, T., Schmidt-Trucksäss, A., Engelter, S. T., & Peters, N. (2023). Self-reported life-space mobility in the first year after ischemic stroke : longitudinal findings from the MOBITEC-Stroke project. Journal of Neurology, 270(8), 3992-4003. https://doi.org/10.1007/s00415-023-11748-5
Published inJournal of Neurology
© The Author(s) 2023
Background Life-space mobility is defined as the size of the area in which a person moves about within a specified period of time. Our study aimed to characterize life-space mobility, identify factors associated with its course, and detect typical trajectories in the first year after ischemic stroke. Methods MOBITEC-Stroke (ISRCTN85999967; 13/08/2020) was a cohort study with assessments performed 3, 6, 9 and 12 months after stroke onset. We applied linear mixed effects models (LMMs) with life-space mobility (Life-Space Assessment; LSA) as outcome and time point, sex, age, pre-stroke mobility limitation, stroke severity (National Institutes of Health Stroke Scale; NIHSS), modified Rankin Scale, comorbidities, neighborhood characteristics, availability of a car, Falls Efficacy Scale-International (FES-I), and lower extremity physical function (log-transformed timed up-and-go; TUG) as independent variables. We elucidated typical trajectories of LSA by latent class growth analysis (LCGA) and performed univariate tests for differences between classes. Results In 59 participants (mean age 71.6, SD 10.0 years; 33.9% women), mean LSA at 3 months was 69.3 (SD 27.3). LMMs revealed evidence (p ≤ 0.05) that pre-stroke mobility limitation, NIHSS, comorbidities, and FES-I were independently associated with the course of LSA; there was no evidence for a significant effect of time point. LCGA revealed three classes: “low stable”, “average stable”, and “high increasing”. Classes differed with regard to LSA starting value, pre-stroke mobility limitation, FES-I, and log-transformed TUG time. Conclusion Routinely assessing LSA starting value, pre-stroke mobility limitation, and FES-I may help clinicians identify patients at increased risk of failure to improve LSA. ...
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Additional information about fundingOpen access funding provided by University of Basel. MOBITEC-Stroke (“Recovery of mobility function and life-space mobility after ischemic stroke”; PI/Co-PI: Timo Hinrichs/Nils Peters) was funded by the Swiss National Science Foundation (SNSF) from August 2019 to July 2022 (Project No. 182681; https://p3.snf.ch/Project-182681). The SNSF had no role in in study design, in the collection, analysis or interpretation of data, in the writing of the report or in the decision to submit the article for publication. ...
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