Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam : a formative approach
Koivunen, K., Hoogendijk, E. O., Schaap, L. A., Huisman, M., Heymans, M. W., & van Schoor, N. M. (2023). Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam : a formative approach. Aging Clinical and Experimental Research, Early online. https://doi.org/10.1007/s40520-023-02366-2
Published inAging Clinical and Experimental Research
© The Author(s) 2023
Background Intrinsic capacity (IC) defined by the WHO refers to the composite of five domains of capacities. So far, developing and validating a standardized overall score of the concept have been challenging partly because its conceptual framework has been unclear. We consider that a person’s IC is determined by its domain-specific indicators suggesting a formative measurement model. Aims To develop an IC score applying a formative approach and assess its validity. Methods The study sample (n = 1908) consisted of 57–88-year-old participants from the Longitudinal Aging Study Amsterdam (LASA). We used logistic regression models to select the indicators to the IC score with 6-year functional decline as an outcome. An IC score (range 0–100) was constructed for each participant. We examined the known-groups’ validity of the IC score by comparing groups based on age and number of chronic diseases. The criterion validity of the IC score was assessed with 6-year functional decline and 10-year mortality as outcomes. Results The constructed IC score included seven indicators covering all five domains of the construct. The mean IC score was 66.7 (SD 10.3). The scores were higher among younger participants and those who had lower number of chronic diseases. After adjustment for sociodemographic indicators, chronic diseases, and BMI, a one-point higher IC score was associated with a 7% decreased risk for 6-year functional decline and a 2% decreased risk for 10-year mortality. Conclusions The developed IC score demonstrated discriminative ability according to age and health status and is associated with subsequent functional decline and mortality. ...
PublisherSpringer Science and Business Media LLC
ISSN Search the Publication Forum1594-0667
Dataset(s) related to the publicationhttps://www.lasa-vu.nl/
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Related funder(s)European Commission; Academy of Finland
Funding program(s)Academy Project, AoF
The content of the publication reflects only the author’s view. The funder is not responsible for any use that may be made of the information it contains.
Additional information about fundingOpen Access funding provided by University of Jyväskylä (JYU). The Longitudinal Aging Study Amsterdam is supported by a grant from the Netherlands Ministry of Health Welfare and Sports, Directorate of Long-Term Care. This work was also supported by the European Research Council ERC Advanced Grant [693045 to Taina Rantanen, JYU], the Academy of Finland [310526 to Taina Rantanen, JYU], and the University of Jyväskylä (JYU) Finland. The content of this manuscript does not reflect the official opinion of the European Union. Responsibility for the information and views expressed in the manuscript lies entirely with the authors. ...
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