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dc.contributor.authorEriksson, Mia D.
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorKorhonen, Päivi
dc.contributor.authorKoponen, Hannu
dc.contributor.authorSalonen, Minna K.
dc.contributor.authorMikkola, Tuija M.
dc.contributor.authorKajantie, Eero
dc.contributor.authorWasenius, Niko S.
dc.contributor.authorvon Bonsdorff, Mikaela
dc.contributor.authorKautiainen, Hannu
dc.contributor.authorLaine, Merja K.
dc.date.accessioned2022-11-09T06:10:53Z
dc.date.available2022-11-09T06:10:53Z
dc.date.issued2023
dc.identifier.citationEriksson, M. D., Eriksson, J. G., Korhonen, P., Koponen, H., Salonen, M. K., Mikkola, T. M., Kajantie, E., Wasenius, N. S., von Bonsdorff, M., Kautiainen, H., & Laine, M. K. (2023). Depressive Symptoms and Mortality : Findings from Helsinki Birth Cohort Study. <i>Acta psychiatrica scandinavica</i>, <i>147</i>(2), 175-185. <a href="https://doi.org/10.1111/acps.13512" target="_blank">https://doi.org/10.1111/acps.13512</a>
dc.identifier.otherCONVID_159378036
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/83824
dc.description.abstractBackground Individuals with depression and depressive symptoms have a higher mortality rate than non-depressed individuals. The increased comorbidity and mortality associated with depression has remained largely unexplained. The underlying pathophysiological differences between depressive subtypes, melancholic and non-melancholic, may provide some explanation to this phenomenon. Methods 1995 participants (mean age 61 years) from the Helsinki Birth Cohort Study were recruited for this prospective study and followed up for a mean of 14.1 years. Information regarding medical history, lifestyle, and biochemical parameters were obtained. Depressive symptoms were assessed using the Beck Depression Inventory. Standardized mortality ratios were calculated. Results Participants were followed up for a total of 28 044 person-years. The melancholic depressive group had an increased adjusted risk of mortality [HR 1.49 (95% CI: 1.02-2.20)] when compared to the non-depressive group. Comparing mortality to the whole population of Finland using standardized mortality ratios (SMR) both the non-melancholic [1.11 (95% CI: 0.85-1.44)] and melancholic depressive [1.26 (95% CI: 0.87-1.81)] groups had higher mortality than the non-depressive group [ 0.82 (95% CI: 0.73-0.93)]. Conclusions Melancholic depressive symptoms are most strongly related to a higher mortality risk.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofseriesActa psychiatrica scandinavica
dc.rightsCC BY 4.0
dc.titleDepressive Symptoms and Mortality : Findings from Helsinki Birth Cohort Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202211095125
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange175-185
dc.relation.issn0001-690X
dc.relation.numberinseries2
dc.relation.volume147
dc.type.versionpublishedVersion
dc.rights.copyright© 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.
dc.rights.accesslevelopenAccessfi
dc.subject.ysostressi
dc.subject.ysokuolleisuus
dc.subject.ysomielenterveysongelmat
dc.subject.ysomasennus
dc.subject.ysoelintavat
dc.subject.ysomielenterveys
dc.subject.ysoterveys
dc.subject.ysomielenterveyshäiriöt
dc.subject.ysoelämäntapa
dc.subject.ysoikääntyminen
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p133
jyx.subject.urihttp://www.yso.fi/onto/yso/p5003
jyx.subject.urihttp://www.yso.fi/onto/yso/p20629
jyx.subject.urihttp://www.yso.fi/onto/yso/p7995
jyx.subject.urihttp://www.yso.fi/onto/yso/p5530
jyx.subject.urihttp://www.yso.fi/onto/yso/p1949
jyx.subject.urihttp://www.yso.fi/onto/yso/p2762
jyx.subject.urihttp://www.yso.fi/onto/yso/p990
jyx.subject.urihttp://www.yso.fi/onto/yso/p8760
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1111/acps.13512
jyx.fundinginformationThe HBCS has been supported by grants from Finska Läkaresällskapet, the Finnish Special Governmental Subsidy for Health Sciences, Academy of Finland (126775, 127437, 129255, 129306, 129907, 130326, 134791, 209072, 210595, 213225, 263924, 275074 and 315690), Samfundet Folkhälsan, Liv och Hälsa, EU FP7 [Developmental Origins of Healthy Aging (DORIAN)] project number 278603, and EU H2020-PHC-2014-DynaHealth grant 633595 and EU Horizon 2020 Award 733206 LIFECYCLE (all for the Helsinki Birth Cohort Study), European Commission, Horizon2020 award 733280 RECAP, Foundation for Cardiovascular Research, Foundation for Diabetes Research, Foundation for Pediatric Research, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation.


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