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dc.contributor.authorAbdelrahman, Shima
dc.contributor.authorPurcell, Mariel
dc.contributor.authorRantalainen, Timo
dc.contributor.authorCoupaud, Sylvie
dc.contributor.authorIreland, Alex
dc.date.accessioned2022-03-24T10:54:39Z
dc.date.available2022-03-24T10:54:39Z
dc.date.issued2022
dc.identifier.citationAbdelrahman, S., Purcell, M., Rantalainen, T., Coupaud, S., & Ireland, A. (2022). Fibula response to disuse : a longitudinal analysis in people with spinal cord injury. <i>Archives of Osteoporosis</i>, <i>17</i>, Article 51. <a href="https://doi.org/10.1007/s11657-022-01095-9" target="_blank">https://doi.org/10.1007/s11657-022-01095-9</a>
dc.identifier.otherCONVID_104671101
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/80355
dc.description.abstractSummary Fibular response to disuse has been described in cross-sectional but not longitudinal studies. This study assessed fbular bone changes in people with spinal cord injury. Fibular bone loss was less than in the tibia and was not correlated together. This might explain low fbular fracture incidents in these patients. Purpose Cross-sectional studies suggest that the fbula responds diferently to loading and disuse compared to the tibia. Whilst tibial bone changes following spinal cord injury (SCI) have been established in longitudinal studies, fbular changes remain unexplored. Methods Fibular and tibial bone parameters were assessed in 13 individuals with SCI (aged 16–76 years). Peripheral quantitative computed tomography scans were acquired at 4%, 38% and 66% distal–proximal tibia length at 5 weeks and 12 months post-injury. Changes in 4% site total bone mineral content (BMC), total cross-sectional area (CSA) and bone mineral density (BMD), and 38% and 66% sites total BMC, total CSA, cortical BMD and cortical CSA were assessed using paired T-tests. Relationships between bone loss in the two bones at equivalent sites were assessed using paired T-tests and correlation. Results At the 4% site, fbular total BMC and BMD losses were less than tibial losses (−6.9±5.1% and−6.6±6.0% vs−14.8±12.4% and−14.4±12.4%, p=0.02 and p=0.03, respectively). Similarly, at the 66% site, fbular BMC losses were less than those in the tibia (−2.0±2.6% vs−4.3±3.6%, p=0.03), but there was no diference at 38% (−1.8±3.5% vs−3.8±2.1%, p=0.1). No correlation was observed for BMC changes between the two bones (all p>0.25). Conclusion These results support cross-sectional evidence of smaller disuse-related bone loss in the fbula compared to the tibia. These results may in part explain lower incidence of fbula fractures in individuals with chronic SCI. The lack of association between losses in the two bones might point to diferent underlying mechanisms.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesArchives of Osteoporosis
dc.rightsCC BY 4.0
dc.subject.otherfibula
dc.subject.otherdisuse osteoporosis
dc.subject.othermechanoadaptation
dc.subject.otherspinal cord injury
dc.subject.otherpQCT
dc.titleFibula response to disuse : a longitudinal analysis in people with spinal cord injury
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202203242042
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineBiomekaniikkafi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineBiomechanicsen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn1862-3522
dc.relation.volume17
dc.type.versionpublishedVersion
dc.rights.copyright© Authors, 2022
dc.rights.accesslevelopenAccessfi
dc.subject.ysoosteoporoosi
dc.subject.ysoselkäydinvammat
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p10781
jyx.subject.urihttp://www.yso.fi/onto/yso/p29389
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1007/s11657-022-01095-9
jyx.fundinginformationThis study was funded by the Glasgow Research Partnership in Engineering.
dc.type.okmA1


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