Show simple item record

dc.contributor.authorLaine, Veronika N.
dc.contributor.authorVerschuuren, Mark
dc.contributor.authorvan Oers, Kees
dc.contributor.authorEspín, Silvia
dc.contributor.authorSánchez-Virosta, Pablo
dc.contributor.authorEeva, Tapio
dc.contributor.authorRuuskanen, Suvi
dc.date.accessioned2021-07-12T10:11:59Z
dc.date.available2021-07-12T10:11:59Z
dc.date.issued2021
dc.identifier.citationLaine, V. N., Verschuuren, M., van Oers, K., Espín, S., Sánchez-Virosta, P., Eeva, T., & Ruuskanen, S. (2021). Does Arsenic Contamination Affect DNA Methylation Patterns in a Wild Bird Population? : An Experimental Approach. <i>Environmental Science and Technology</i>, <i>55</i>(13), 8947-8954. <a href="https://doi.org/10.1021/acs.est.0c08621" target="_blank">https://doi.org/10.1021/acs.est.0c08621</a>
dc.identifier.otherCONVID_97830321
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/77100
dc.description.abstractPollutants, such as toxic metals, negatively influence organismal health and performance, even leading to population collapses. Studies in model organisms have shown that epigenetic marks, such as DNA methylation, can be modulated by various environmental factors, including pollutants, influencing gene expression, and various organismal traits. Yet experimental data on the effects of pollution on DNA methylation from wild animal populations are largely lacking. We here experimentally investigated for the first time the effects of early-life exposure to environmentally relevant levels of a key pollutant, arsenic (As), on genome-wide DNA methylation in a wild bird population. We experimentally exposed nestlings of great tits (Parus major) to arsenic during their postnatal developmental period (3 to 14 days post-hatching) and compared their erythrocyte DNA methylation levels to those of respective controls. In contrast to predictions, we found no overall hypomethylation in the arsenic group. We found evidence for loci to be differentially methylated between the treatment groups, but for five CpG sites only. Three of the sites were located in gene bodies of zinc finger and BTB domain containing 47 (ZBTB47), HIVEP zinc finger 3 (HIVEP3), and insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1). Further studies are needed to evaluate whether epigenetic dysregulation is a commonly observed phenomenon in polluted populations and what are the consequences for organism functioning and for population dynamics.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS)
dc.relation.ispartofseriesEnvironmental Science and Technology
dc.rightsCC BY 4.0
dc.subject.otherpollution
dc.subject.otherParus major
dc.subject.otherenvironmental epigenetics
dc.subject.otherecological epigenetics
dc.subject.otherecotoxicology
dc.titleDoes Arsenic Contamination Affect DNA Methylation Patterns in a Wild Bird Population? : An Experimental Approach
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202107124285
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange8947-8954
dc.relation.issn0013-936X
dc.relation.numberinseries13
dc.relation.volume55
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 The Authors. Published by American Chemical Society
dc.rights.accesslevelopenAccessfi
dc.subject.ysoekotoksikologia
dc.subject.ysoympäristön saastuminen
dc.subject.ysoepigenetiikka
dc.subject.ysoarseeni
dc.subject.ysotalitiainen
dc.subject.ysohaitalliset aineet
dc.subject.ysoDNA-metylaatio
dc.subject.ysovillieläimet
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p19671
jyx.subject.urihttp://www.yso.fi/onto/yso/p4340
jyx.subject.urihttp://www.yso.fi/onto/yso/p24631
jyx.subject.urihttp://www.yso.fi/onto/yso/p9329
jyx.subject.urihttp://www.yso.fi/onto/yso/p12931
jyx.subject.urihttp://www.yso.fi/onto/yso/p7067
jyx.subject.urihttp://www.yso.fi/onto/yso/p38350
jyx.subject.urihttp://www.yso.fi/onto/yso/p6918
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1021/acs.est.0c08621
jyx.fundinginformationThis study was financed by KONE foundation (S.R.) and Academy of Finland (T.E.: project 265859). S.E. is currently funded by Ministerio de Ciencia, Innovación y Universidades (IJCI-2017-34653 to S.E.).


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY 4.0
Except where otherwise noted, this item's license is described as CC BY 4.0