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dc.contributor.authorConstable, Annie M.
dc.contributor.authorPorter, Josie E.
dc.contributor.authorBenger, Danielle
dc.contributor.authorVlachopoulos, Dimitris
dc.contributor.authorBarker, Alan R.
dc.contributor.authorMoore, Sarah A.
dc.contributor.authorSoininen, Sonja
dc.contributor.authorHaapala, Eero A.
dc.contributor.authorWestgate, Kate
dc.contributor.authorBrage, Soren
dc.contributor.authorAgostinete, Ricardo R.
dc.contributor.authorFernandes, Romulo A.
dc.contributor.authorLakka, Timo A.
dc.date.accessioned2021-06-10T06:25:25Z
dc.date.available2021-06-10T06:25:25Z
dc.date.issued2021
dc.identifier.citationConstable, A. M., Porter, J. E., Benger, D., Vlachopoulos, D., Barker, A. R., Moore, S. A., Soininen, S., Haapala, E. A., Westgate, K., Brage, S., Agostinete, R. R., Fernandes, R. A., & Lakka, T. A. (2021). The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children : The PANIC Study. <i>International Journal of Environmental Research and Public Health</i>, <i>18</i>(10), Article 5365. <a href="https://doi.org/10.3390/ijerph18105365" target="_blank">https://doi.org/10.3390/ijerph18105365</a>
dc.identifier.otherCONVID_97246138
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/76408
dc.description.abstractPurpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of this study was to examine whether the relationship between MVPA and total body less head (TBLH) BMC is mediated or moderated by free leptin index in prepubertal children. Methods: We performed a cross-sectional analysis on 401 children (194 girls) from baseline examinations of the Physical Activity and Nutrition in Childhood Study. We applied the four-way decomposition mediation analysis method to assess whether free leptin index, measured from fasted blood samples, mediated the relationship between accelerometer-measured MVPA and TBLH BMC measured by dual-energy X-ray absorptiometry. Results: MVPA had a positive controlled direct effect on TBLH BMC in girls and boys (β = 0.010 to 0.011, p < 0.05). There was no mediation or interaction between MVPA, free leptin index and TBLH BMC in girls or boys (β = −0.000 to 0.001, p > 0.05). Conclusion: Our study indicates that MVPA positively influences TBLH BMC through pathways not related to free leptin index in predominantly normal-weight prepubertal children, likely primarily through mechanical loading. The relationships between MVPA, free leptin index and TBLH BMC may be influenced by other factors such as pubertal status and adiposity, so it is unknown whether these observations extend to overweight and obese children at different stages of puberty.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.ispartofseriesInternational Journal of Environmental Research and Public Health
dc.rightsCC BY 4.0
dc.subject.otherprepubertal age
dc.subject.otherfree leptin index
dc.subject.otheraccelerometery
dc.subject.otherbone mass
dc.subject.otherchildhood
dc.subject.otherDXA
dc.subject.othergrowth
dc.titleThe Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children : The PANIC Study
dc.typeresearch article
dc.identifier.urnURN:NBN:fi:jyu-202106103617
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineBiomekaniikkafi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineBiomechanicsen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn1661-7827
dc.relation.numberinseries10
dc.relation.volume18
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.rights.accesslevelopenAccessfi
dc.type.publicationarticle
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysoluu
dc.subject.ysolapset (ikäryhmät)
dc.subject.ysoleptiini
dc.subject.ysoluuntiheys
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p24244
jyx.subject.urihttp://www.yso.fi/onto/yso/p4354
jyx.subject.urihttp://www.yso.fi/onto/yso/p11607
jyx.subject.urihttp://www.yso.fi/onto/yso/p22879
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/ijerph18105365
jyx.fundinginformationThis work was financially supported by grants from Ministry of Social Affairs and Health of Finland, Ministry of Education and Culture of Finland, Finnish Innovation Fund Sitra, Social Insurance Institution of Finland, Finnish Cultural Foundation, Juho Vainio Foundation, Foundation for Paediatric Research, Doctoral Programs in Public Health, Paavo Nurmi Foundation, Paulo Foundation, Diabetes Research Foundation, The Finnish Medical Society Duodecim, Orion Research Foundation sr, Research Committee of the Kuopio University Hospital Catchment Area (State Research Funding), Kuopio University Hospital (previous state research funding (EVO), funding number 5031343) and the city of Kuopio. The UEF LC-MS Metabolomics laboratory is supported by Biocenter Finland and Biocenter Kuopio. S. B. and K. W. were supported by the UK Medical Research Council (MC_UU_12015/3) and the NIHR Cambridge Biomedical Research Centre (IS-BRC-1215-20014). R.R.A. was supported by the São Paulo Research Foundation-FAPESP (Process: 2017/09182-5 and 2018/24164-6).
dc.type.okmA1


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